Increase of serum CA19-9 level without an evident lesion on conventional imaging is insufficient for justification of 18FDG-PET examination.
Increase of serum CA19-9 level without an evident lesion on conventional imaging is insufficient for justification of 18FDG-PET examination.
复制标题
DOI：
--
复制
发表时间：
2008
影响因子：
--
通讯作者：
Kentaro Inoue;K. Okada;Y. Taki;R. Goto;S. Kinomura;T. Kaneta;H. Fukuda
中科院分区：
文献类型：
--
作者：
Kentaro Inoue;K. Okada;Y. Taki;R. Goto;S. Kinomura;T. Kaneta;H. Fukuda
背景与目的血清肿瘤标志物糖类相关抗原19-9（carbohydrate associated antigen 19 - 9，CA 19 -9）已被用于癌症筛查，因为其升高与许多癌症相关。我们的目的是评估使用F-18氟脱氧葡萄糖（18 FDG-PET）的正电子发射断层扫描的临床价值，该断层扫描是由血清CA 19 -9升高引起的，而常规成像没有发现。方法回顾性选择22例患者。11例无癌症病史，11例有癌症病史，并接受了治疗。所有18例FDG-PET结果均与手术或活检的组织病理学结果或至少1年的临床随访结果进行比较。结果：我们发现只有2例真阳性病例，11例无癌症病史的病例中，10例真阴性，1例假阳性。结论血清CA 19 -9升高可由多种良性疾病引起。CA 19 -9升高而常规影像学无发现，不能作为18FDG-PET检查的依据，特别是在无癌症史的患者中。
BACKGROUND/AIMS The serum tumor marker carbohydrate associated antigen 19-9 (CA19-9) has been used for screening for cancer, because its increase has been associated with many cancers. We aimed to evaluate the clinical value of positron emission tomography using F-18 fluorodeoxyglucose (18FDG-PET) that was prompted by increases of serum CA19-9 without findings on conventional imaging. METHODOLOGY Twenty-two patients were retrospectively selected. Eleven were without a history of cancer and eleven had a history of cancer and were treated with curative intent. All 18FDG-PET findings were compared with the findings of histopathology by surgery or biopsy, or clinical follow-up for at least 1 year. RESULTS We found only two true positive cases, and eleven cases without a cancer history included 10 true negatives and one false positive. CONCLUSIONS Increases in serum CA19-9 are caused by many benign conditions. Increases of CA19-9 without findings on conventional imaging do not justify 18FDG-PET examination, particularly in patients without a cancer history.