The Development, Commercialization, and Impact of Optical Coherence Tomography.
The Development, Commercialization, and Impact of Optical Coherence Tomography.
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DOI：
10.1167/iovs.16-19963
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发表时间：
2016-07-01
影响因子：
4.4
通讯作者：
Swanson E
中科院分区：
文献类型：
--
作者：
Fujimoto J;Swanson E
这篇综述是为IOVS特刊撰写的，从非科学的历史角度描述了光学相干断层扫描（OCT）的历史及其演变。光学相干断层扫描已成为眼科的标准治疗，提供有关结构和功能的实时信息-诊断疾病，评估进展，评估对治疗的反应，以及帮助了解疾病的发病机制和创造新的治疗方法。光学相干断层扫描还可应用于多个临床专业、基础研究和制造业。我们回顾了OCT的早期历史，描述了研究和开发的演变以及多学科合作和专业知识的重要作用。光学相干断层扫描起源于飞秒光学，但使用光学通信技术，并需要早期OCT原型，临床可行性研究，创业和企业发展的先进工程，以实现临床接受和临床影响。早期职业研究人员、临床科学家、工程专家和商界领袖取得了重大进展，使OCT对医疗保健产生了全球影响。我们引入了“生态系统”的概念，包括研究，政府资助，合作和竞争，临床研究，创新，创业和产业，以及影响-所有这些都必须协同工作。我们叙述的过程是漫长而具有挑战性的，但我们希望它可能会激励科学，工程和医学的早期职业专业人士，临床和研究界将发现这篇评论的兴趣。
This review was written for the special issue of IOVS to describe the history of optical coherence tomography (OCT) and its evolution from a nonscientific, historic perspective. Optical coherence tomography has become a standard of care in ophthalmology, providing real-time information on structure and function – diagnosing disease, evaluating progression, and assessing response to therapy, as well as helping to understand disease pathogenesis and create new therapies. Optical coherence tomography also has applications in multiple clinical specialties, fundamental research, and manufacturing. We review the early history of OCT describing how research and development evolves and the important role of multidisciplinary collaboration and expertise. Optical coherence tomography had its origin in femtosecond optics, but used optical communications technologies and required advanced engineering for early OCT prototypes, clinical feasibility studies, entrepreneurship, and corporate development in order to achieve clinical acceptance and clinical impact. Critical advances were made by early career researchers, clinician scientists, engineering experts, and business leaders, which enabled OCT to have a worldwide impact on health care. We introduce the concept of an “ecosystem” consisting of research, government funding, collaboration and competition, clinical studies, innovation, entrepreneurship and industry, and impact – all of which must work synergistically. The process that we recount is long and challenging, but it is our hope that it might inspire early career professionals in science, engineering, and medicine, and that the clinical and research community will find this review of interest.