Antibodies to voltage-gated potassium and calcium channels in epilepsy
Antibodies to voltage-gated potassium and calcium channels in epilepsy
复制标题
DOI：
10.1016/j.eplepsyres.2006.06.003
复制
发表时间：
2006-10-01
影响因子：
2.2
通讯作者：
Vincent, Angela
中科院分区：
文献类型：
--
作者：
Majoie, H. J. Marian;de Baets, Mark;Vincent, Angela
目的：确定长期癫痫患者中离子通道抗体的患病率。背景：虽然中枢神经系统被认为可以通过血脑屏障免受循环抗体的影响，但在拉斯穆森脑炎中发现了谷氨酸受体抗体，在少数癫痫患者中发现了谷氨酸脱羧酶（GAD）抗体，在非副肿瘤性边缘系统中发现了电压门控钾通道（VGKC）抗体方法：我们回顾性筛查了女性癫痫患者 (n = 106) 的血清中 VGKC（Kv 1.1、1.2 或 1.6）、电压门控钙通道 (VGCC)（P/Q 型）和 GAD 的自身抗体。所有阳性结果均基于对照数据的值 [McKnight, K., Jiang, Y, et al. （2005）。癫痫和癫痫相关疾病的血清抗体。 Neurology 65, 1730-1735]，在较低的血清浓度下重新测试，并将结果与之前发表的对照数据进行比较。收集了人口统计、病史和癫痫相关信息。结果：研究组主要由长期耐药性癫痫患者组成。 6 名患者的 VGKC 抗体升高（> 100 pM）。仅一名患者的 VGCC 抗体 (> 45 pM) 略有升高。所有患者的 GAD 抗体均< 3 U/ml。 VGKC 抗体患者的临床特征与之前描述的边缘脑炎样综合征患者不同，并且在癫痫发作类型、首次癫痫发作年龄、癫痫持续时间或使用抗癫痫药物方面与 VGKC 抗体阴性患者没有差异。 结论：结果表明 6% 的典型长期癫痫患者存在 VGKC 抗体，但这些抗体是致病性的还是继发于原发疾病过程的，需要进一步研究。确定。 (c) 2006 Elsevier B.V. 保留所有权利。
Objective: To determine the prevalence of antibodies to ion channels in patients with long standing epilepsy.Background: Although the CNS is thought to be protected from circulating antibodies by the blood brain barrier, glutamate receptor antibodies have been reported in Rasmussen's encephalitis, glutamic acid decarboxylase (GAD) antibodies have been found in a few patients with epilepsy, and antibodies to voltage-gated potassium channels (VGKC) have been found in a non-paraneoplastic form of limbic encephalitis (with amnesia and seizures) that responds to immunosuppressive therapy.Methods: We retrospectively screened sera from female epilepsy patients (n = 106) for autoantibodies to VGKC (Kv 1.1, 1.2 or 1.6), voltage-gated calcium channels (VGCC) (P/Q-type), and GAD. All positive results, based on the values of control data [McKnight, K., Jiang, Y, et al. (2005). Serum antibodies in epilepsy and seizure-associated disorders. Neurology 65, 1730-1735], were retested at lower serum concentrations, and results compared with previously published control data. Demographics, medical history, and epilepsy related information was gathered.Results: The studied group consisted predominantly of patients with long standing drug resistant epilepsy. VGKC antibodies were raised (> 100 pM) in six patients. VGCC antibodies (> 45 pM) were slightly raised in only one patient. GAD antibodies were < 3 U/ml in all patients. The clinical features of the patients with VGKC antibodies differed from previously described patients with limbic encephalitis-like syndrome, and were not different with respect to seizure type, age at first seizure, duration of epilepsy, or use of anti-epileptic drugs from the VGKC antibody negative patients.Conclusion: The results demonstrate that antibodies to VGKC are present in 6% of patients with typical long-standing epilepsy, but whether these antibodies are pathogenic or secondary to the primary disease process needs to be determined. (c) 2006 Elsevier B.V. All rights reserved.