Molecular determinants of the physiological adaptation to stress in the cardiomyocyte: a focus on AKT
Molecular determinants of the physiological adaptation to stress in the cardiomyocyte: a focus on AKT
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DOI：
10.1016/j.yjmcc.2004.06.020
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发表时间：
2004-11-01
影响因子：
5
通讯作者：
Condorelli, G
中科院分区：
文献类型：
--
作者：
Ceci, M;Ross, J;Condorelli, G
心肌细胞（CMCs）通过发生分子变化来适应生理或病理刺激，这些分子变化根据刺激的特异性而分化，并最终产生具有特殊分子特征的表型。在这里，我们回顾了CMC在生理适应应激过程中激活的分子机制，而不是适应不良的文献。本文描述了IGF-1受体/PI3K/Akt信号通路在这一过程中的关键作用，包括调节肌力变性和细胞大小的效应靶点。(C) 2004 Elsevier Ltd.版权所有。
Cardiomyocytes (CMCs) adapt to physiological or pathological stimuli by undergoing molecular changes which differentiate according to the specificity of the stimulus and eventually generate a phenotype with peculiar molecular characteristics. Here, we review the literature on the molecular mechanisms activated in the CMC during physiologic adaptation to stress, as opposed to maladaptation. The critical role of the IGF-1 receptor/PI3K/Akt signaling pathway during this process is described, including effector targets regulating inotropism and cell size. (C) 2004 Elsevier Ltd. All rights reserved.