Precision neuromodulation: Promises and challenges of spinal stimulation for multi-modal rehabilitation.
Precision neuromodulation: Promises and challenges of spinal stimulation for multi-modal rehabilitation.
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精确神经调节：脊髓刺激对多模式康复的承诺和挑战。
DOI：
10.3389/fresc.2023.1135593
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
McPherson JG
中科院分区：
文献类型：
--
作者：
Bandres MF;Gomes JL;Moreno Romero GN;Twyman AR;McPherson JG
脊髓损伤会导致多种同时发生的感觉运动缺陷。这些包括但不限于病变下方肌肉的完全或部分麻痹、肌肉痉挛、痉挛和神经性疼痛。肠道、膀胱和性功能障碍也很常见。然而，大多数新兴的基于脊柱刺激的疗法都集中在一个问题上：运动康复。尽管这些转化进展具有改变脊髓损伤患者生活的巨大潜力，但在其他被视为关键优先事项的领域仍然缺乏有意义的恢复。在这里，我们强调在开发基于脊髓刺激的疗法时考虑临床相似表现背后的不同神经传递模式的重要性。我们还推动多模式康复范例的发展，该范例利用感觉运动脊柱网络的密集互连性和电刺激调节这些网络的独特能力，以促进和指导跨领域的同步康复。
Spinal cord injury results in multiple, simultaneous sensorimotor deficits. These include, but are not limited to, full or partial paralysis of muscles below the lesion, muscle spasms, spasticity, and neuropathic pain. Bowel, bladder, and sexual dysfunction are also prevalent. Yet, the majority of emerging spinal stimulation-based therapies focus on a single issue: locomotor rehabilitation. Despite the enormous potential of these translational advances to transform the lives of people living with spinal cord injury, meaningful recovery in other domains deemed critical priorities remains lacking. Here, we highlight the importance of considering the diverse patterns of neural transmission that underlie clinically similar presentations when developing spinal stimulation-based therapies. We also motivate advancement of multi-modal rehabilitation paradigms, which leverage the dense interconnectivity of sensorimotor spinal networks and the unique ability of electrical stimulation to modulate these networks to facilitate and guide simultaneous rehabilitation across domains.
影响因子：
4
作者：
Bandres, Maria F.;Gomes, Jefferson L.;McPherson, Jacob G.
通讯作者：
McPherson, Jacob G.