Changes in cell-mediated immunity in kidney transplant recipients with active CMV infection
Changes in cell-mediated immunity in kidney transplant recipients with active CMV infection
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DOI：
10.1111/j.1574-695x.2002.tb00554.x
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发表时间：
2002-02-18
影响因子：
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通讯作者：
Said, T
中科院分区：
文献类型：
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作者：
Essa, S;Raghupathy, R;Said, T
本研究旨在确定（a）外周血单核细胞（PBMC）对巨细胞病毒（CMV）感染的成纤维细胞刺激的增殖程度和（B）有和无活动性CMV感染的肾移植受者的Th1和Th2细胞因子产生水平。30例患者，和39个没有活动性CMV感染，诊断CMV抗原血症测定（AA），进行了研究。活动性CMV感染组PBMC增殖能力明显低于非活动性CMV感染组（P
This study was aimed at determining (a) the extent of proliferation of peripheral blood mononuclear cells (PBMC) in response to stimulation by cytomegalovirus (CMV)-infected fibroblasts and (b) the levels of Th1 and Th2 cytokine production in kidney transplant recipients with and without active CMV infection. Thirty patients with, and 39 without active CMV infection, diagnosed by a CMV antigenemia assay (AA), were studied. PBMC of patients with active CMV infection showed significantly lower proliferation than those without ongoing CMV infection (P