Expression and prognostic significance of MAP4K4 in lung adenocarcinoma
Expression and prognostic significance of MAP4K4 in lung adenocarcinoma
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MAP4K4在肺腺癌中的表达及预后意义
DOI：
10.1016/j.prp.2012.06.001
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发表时间：
2012-01-01
影响因子：
2.8
通讯作者：
Zhang, Shu-Hui
中科院分区：
文献类型：
--
作者：
Qiu, Mei-Hua;Qian, Yi-Ming;Zhang, Shu-Hui
越来越多的证据表明，有丝分裂原活化蛋白4激酶4（MAP4K4）在许多类型的人类癌症中频繁过表达，并在转化、侵袭、粘附和细胞迁移中起重要作用。本研究旨在探讨MAP4K4在肺腺癌中的表达及其与预后的关系。实时定量PCR和Western blotting分析的结果显示，在转录和翻译水平上，MAP4K4在肺腺癌中的表达相对于邻近的非肿瘤肺组织增强。免疫组化结果显示，309例肺腺癌中有130例（42%）表达MAP4K4。MAP4K4过表达与组织学分级（p = 0.027）、pT状态（p = 0.048）、pN状态（p = 0.006）和胸膜浸润（p = 0.024）显著相关。与MAP4K4低表达患者相比，MAP4K4高表达患者的总生存期较短，无论组织学分级、pT状态、pN状态或胸膜浸润状态如何。多因素分析显示MAP4K4是肺腺癌的独立预后因素。总之，我们的研究结果表明，MAP4K4表达升高与肺腺癌进展密切相关，并在预测肺腺癌患者的总生存率方面具有独立的预后价值。(C)2012年爱思唯尔有限公司。All rights reserved.
Accumulating evidence indicates that mitogen-activated protein 4 kinase 4 (MAP4K4) is frequently over-expressed in many types of human cancers, and plays important roles in transformation, invasiveness, adhesion, and cell migration. The aim of the present study was to explore the expression and prognostic significance of MAP4K4 in lung adenocarcinoma. The results of real-time quantitative PCR and Western blotting analysis revealed an enhanced expression of MAP4K4 in lung adenocarcinomas relative to adjacent non-tumorous lung tissues at both transcriptional and translational levels. Immunohistochemistry showed that 130 of 309 (42%) lung adenocarcinomas had high expression of MAP4K4. MAP4K4 overexpression was significantly correlated with histological grade (p = 0.027), pT status (p = 0.048), pN status (p = 0.006), and pleural invasion (p = 0.024). Patients with high MAP4K4 expression had a shorter overall survival compared with those with low MAP4K4 expression, regardless of histological grade, pT status, pN status, or pleural invasion status. Multivariate analysis identified MAP4K4 as an independent prognostic factor for lung adenocarcinoma. In conclusion, our results demonstrate that elevated MAP4K4 expression is closely associated with lung adenocarcinoma progression and has an independent prognostic value in predicting overall survival for patients with lung adenocarcinoma. (C) 2012 Elsevier GmbH. All rights reserved.