Glucocorticoids and their actions in cells.
Glucocorticoids and their actions in cells.
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DOI：
10.1097/iae.0b013e3181ad2636
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发表时间：
2009-06-01
期刊：
影响因子：
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通讯作者：
Cidlowski, John A
中科院分区：
文献类型：
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作者：
Cidlowski, John A
外源性糖皮质激素（GC）给药的生物学反应似乎是特定的细胞类型。因此，在理解如何提高GC治疗眼睛的获益风险比方面的进展将取决于受体和这些受体被刺激时诱导的蛋白质的更好表征。人体组织中GC受体的复杂性和多样性得到了以下证据的强调：在GC暴露的数小时内，多达6，000个基因被表达或抑制。使用外源性GC药物下调年龄相关性黄斑变性过程的巨大潜力必须与类似的潜在反作用相平衡。最近的进展预测，GC类固醇可以用来影响生物功能的精度越来越高。
The biologic responses to the administration of exogenous glucocorticoids (GCs) appear to be specific to cell type. As a result, progress in understanding how to improve the benefit-to-risk ratio of GC therapies for the eye will depend on better characterization of both the receptors and the proteins induced when these receptors are stimulated. The complexity and diversity of the GC receptors in human tissue is underscored by evidence that up to 6,000 genes are expressed or suppressed within hours of GC exposure. The enormous potential to use exogenous GC agents to downregulate processes involved in age-related macular degeneration must be balanced against a similar potential for counterproductive effects. Recent progress predicts an increasing precision with which GC steroids can be used to influence biologic functions.