Feasibility of Home-Based Computerized Working Memory Training With Children and Adolescents With Sickle Cell Disease
Feasibility of Home-Based Computerized Working Memory Training With Children and Adolescents With Sickle Cell Disease
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DOI：
10.1002/pbc.26019
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发表时间：
2016-09-01
影响因子：
3.2
通讯作者：
Meier, Emily R.
中科院分区：
文献类型：
--
作者：
Hardy, Steven J.;Hardy, Kristina K.;Meier, Emily R.
背景患有镰状细胞病（SCD）的儿童神经认知缺陷的风险增加，但描述改善这些问题和促进学业成绩的干预措施的文献有限。我们评估的可行性和初步疗效的家庭为基础的计算机工作记忆（WM）训练干预（Cogmed）在儿童SCD.ProcedureYouth与SCD之间的7岁和16岁完成了初步的神经心理学评估;那些与WM赤字借给iPad上，他们在家里访问Cogmed。参与者被指示每周在Cogmed上工作5天，持续5周（25次培训课程）。我们研究了Cogmed的使用特点和变化WM评估scores after intervention.ResultsOf的21名参与者（M年龄= 11.38，SD = 2.78; Mdn年龄= 10.00，四分位数间距[IQR] = 5.00; 52%女性）筛选，60%表现出WM赤字（n = 12），并收到了干预和50%（n = 6）完成Cogmed。完成的平均疗程数为15.83（SD = 7.73; Mdn = 17.00，IQR = 16.00）;女性更有可能完成Cogmed，（2）（1）= 6.00，P = 0.01。报告较低SCD相关疼痛影响的参与者完成了更多的会话（r = 0.71，P = 0.01）。完成Cogmed的儿童表现出言语WM，视觉空间短期记忆，视觉空间WM.ConclusionsInitial研究结果表明，Cogmed与WM改善青年SCD，但是，坚持低于预期。以家庭为基础的WM干预措施可能会改善SCD相关的WM赤字，但需要解决的障碍，以计划完成的战略。(C)2016 Wiley Periodicals，Inc.
BackgroundChildren with sickle cell disease (SCD) are at increased risk for neurocognitive deficits, yet the literature describing interventions to ameliorate these problems and promote academic achievement is limited. We evaluated the feasibility and preliminary efficacy of a home-based computerized working memory (WM) training intervention (Cogmed) in children with SCD.ProcedureYouth with SCD between the age of 7 and 16 years completed an initial neuropsychological assessment; those with WM deficits were loaned an iPad on which they accessed Cogmed at home. Participants were instructed to work on Cogmed 5 days each week for 5 weeks (25 training sessions). We examined Cogmed usage characteristics and change on WM assessment scores following the intervention.ResultsOf the 21 participants (M age = 11.38, SD = 2.78; Mdn age = 10.00, interquartile range [IQR] = 5.00; 52% female) screened, 60% exhibited WM deficits (n = 12) and received the intervention and 50% (n = 6) completed Cogmed. The mean number of sessions completed was 15.83 (SD = 7.73; Mdn = 17.00, IQR = 16.00); females were more likely to complete Cogmed, (2)(1) = 6.00, P = 0.01. Participants who reported lower SCD-related pain impact completed more sessions (r = 0.71, P = 0.01). Children who completed Cogmed exhibited improvements in verbal WM, visuospatial short-term memory, and visuospatial WM.ConclusionsInitial findings suggest Cogmed is associated with WM improvement in youth with SCD; however, adherence was lower than expected. Home-based WM interventions may ameliorate SCD-related WM deficits but strategies are needed to address barriers to program completion. (C) 2016 Wiley Periodicals, Inc.