Chemistry and weak antimicrobial activities of phomopsins produced by mangrove endophytic fungus Phomopsis sp ZSU-H76
Chemistry and weak antimicrobial activities of phomopsins produced by mangrove endophytic fungus Phomopsis sp ZSU-H76
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红树林内生真菌拟茎点霉 ZSU-H76 产生的拟茎点霉的化学和弱抗菌活性
DOI：
10.1016/j.phytochem.2008.02.002
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发表时间：
2008-05-01
期刊：
影响因子：
3.8
通讯作者：
Lin, Yongcheng
中科院分区：
文献类型：
--
作者：
Huang, Zhongjing;Cai, Xiaoling;Lin, Yongcheng
从采自中国南海的红树林内生真菌拟茎点霉（Phomopsis sp.）ZSU-H76中分离得到3个代谢产物，分别命名为Phomopsin A（1）、B（2）和C（3），以及2个已知化合物cytosporone B（4）和C（5）。通过波谱方法，主要是1D和2D NMR波谱技术，对它们的结构进行了鉴定。基于I或2的中等大小的环状酚醚在天然产物中是罕见的。在生物测定中，化合物1、2和3没有显著的抗菌活性，但化合物4和5抑制两种真菌白色念珠菌和尖孢镰刀菌，MIC范围为32 - 64 μ g/ml。(C)2008年由Elsevier Ltd.出版
Three metabolites named phomopsin A (1), B (2) and C (3), together with two known compounds cytosporone B (4) and C (5), were isolated from the mangrove endophytic fungus, Phomopsis sp. ZSU-H76 obtained from the South China Sea. Their structures were elucidated by spectroscopic methods, mainly by 1D and 2D NMR spectroscopic techniques. The medium-sized cyclic phenol ether based on I or 2 is rare in natural products. In bioassays, compounds 1, 2, and 3 had no significant antibiotic activities, but compounds 4 and 5 inhibited two fungi Candida albicans and Fusarium oxysporum with an MIC ranging from 32 to 64 mu g/ml. (C) 2008 Published by Elsevier Ltd.