Evaluation of Renal Transplant Scintigraphy and Resistance Index Performed Within 2 Days After Transplantation in Predicting Long-Term Graft Function
Evaluation of Renal Transplant Scintigraphy and Resistance Index Performed Within 2 Days After Transplantation in Predicting Long-Term Graft Function
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DOI：
10.1097/rlu.0000000000000789
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发表时间：
2015-07-01
影响因子：
10.6
通讯作者：
Yazici, Ayse
中科院分区：
文献类型：
--
作者：
Yazici, Bulent;Oral, Aylin;Yazici, Ayse
目的移植肾血流图及阻力指数（RI）对移植肾功能的评价是众所周知的。本研究的目的是评价肾移植肾造影和RI对移植肾长期功能的预测价值。资料与方法对119例患者的临床资料进行回顾性分析。术后2d内分别行移植肾核素显像和彩色多普勒超声检查。分别于术后3个月、1年、5年测定肾动脉阻力指数、肾动脉造影灌注/肾图曲线分析结果，并与血清肌酐（sCr）水平进行比较。sCr水平超过1.5 mg/dL被认为是异常的。结果高sCr组（> 1.5mg/dL）移植肾冲洗时间T1/2（GW 1/2）、峰值血流灌注时间与动脉计数时间差（P值）、累积指数（R20/3）差异有统计学意义（P < 0.01）。与随访sCr水平的相关性有统计学意义（P < 0.01）。高灌注曲线分级的受者数量在高sCr水平的随访组中也是显著的。但随访组间RI均值差异无统计学意义，RI与sCr水平无相关性。结论肾移植术后2d内行肾动脉造影可预测移植肾3个月、1年、5年的远期功能，且优于阻力指数上级。
Purpose Value of renal transplant scintigraphy and resistance index (RI) in the assessment of renal graft function is well known. The aim of this study was to evaluate the predictive value of renal transplant scintigraphy and RI for long-term graft function. Materials and Methods A total of 119 patients were analyzed retrospectively. Renal transplant scintigraphy with technetium Tc 99 m DTPA and color Doppler ultrasonography for RI were performed to each patient within 2 days after transplantation. Resistance index and the results of the tests in perfusion/renographic curve analysis of scintigraphy were compared with the serum creatinine (sCr) levels at 3 months, 1 year, and 5 years after transplantation. A sCr level of more than 1.5 mg/dL was considered abnormal. Results Differences of the mean values of T1/2 of graft washout (GW1/2), time difference between peak renal perfusion and arterial count ( increment P), and accumulation index (R20/3) were significantly high in patients with high follow-up sCr (>1.5 mg/dL) (P < 0.01). The correlation of these tests with the follow-up sCr levels was significant (P < 0.01). The number of recipients with high perfusion curve grade was also significant in the follow-up groups with high sCr levels. However, difference of the mean value of RI was insignificant between the follow-up groups, and there was no correlation between the RI and sCr levels. Conclusion Renal transplant scintigraphy performed within 2 days after transplantation is useful in the prediction of long-term graft function at 3 months, 1 year, and 5 years; and it is superior to resistance index.