Alcohol can inhibit effect of IL-4 on activated murine B cells.
Alcohol can inhibit effect of IL-4 on activated murine B cells.
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酒精可以抑制 IL-4 对活化的小鼠 B 细胞的作用。
DOI：
10.1007/bf02918616
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发表时间：
1992
影响因子：
4.4
通讯作者：
Hardwick,J
中科院分区：
文献类型：
--
作者：
Aldo-Benson,M;Pratt,L;Hardwick,J
体外添加乙醇抑制B淋巴细胞抗原诱导的抗体分泌和抗原诱导的细胞增殖。我们通过将乙醇添加到IL-2和IL-4的体外功能测定中，验证了乙醇可以抑制白细胞介素对b细胞增殖的作用的假设。乙醇不抑制il -2诱导的b细胞分化，但抑制il -4诱导的b细胞增殖和il -4诱导的Ig类转换。
Ethanol addition to B lymphocytes in vitro inhibits antigen-induced antibody secretion and antigen-induced cell proliferation. We tested the hypothesis that ethanol can inhibit the effect of interleukins on B-cell proliferation by adding ethanol to in vitro functional assays for IL-2 and IL-4. Ethanol does not inhibit IL-2-induced B-cell differentiation, but it does inhibit IL-4-induced B-cell proliferation and IL-4-induced Ig class switching.