Changed cerebral function and morphology serve as neuroimaging evidence for subclinical type 2 diabetic polyneuropathy.
Changed cerebral function and morphology serve as neuroimaging evidence for subclinical type 2 diabetic polyneuropathy.
复制标题
脑功能和形态的改变可作为亚临床 2 型糖尿病多发性神经病的神经影像学证据
DOI：
10.3389/fendo.2022.1069437
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发表时间：
2022
影响因子：
5.2
通讯作者：
Wu, Jing
中科院分区：
文献类型：
--
作者：
Zhao, Lin-Mei;Chen, Xin;Zhang, You-Ming;Qu, Min-Li;Selvarajah, Dinesh;Tesfaye, Solomon;Yang, Fang-Xue;Ou, Chu-Ying;Liao, Wei-Hua;Wu, Jing
关键词：
介绍中枢和外周神经系统都参与了2型糖尿病多发性神经病的机制，但这种亚临床变化和协会仍然未知。本研究旨在探讨中枢和外周的亚临床变化，并揭示它们之间的联系。方法55例2型糖尿病患者，其中有症状糖尿病23例，亚临床糖尿病12例，无多发性神经病变20例。收集大脑形态、功能、外周电生理和临床信息，并使用ANOVA和事后分析进行评估。高斯随机场校正用于多重比较校正。Pearson/斯皮尔曼相关分析用于评估大脑与外周的关联。结果亚临床组与无多发性神经病组比较，除胫神经波幅外，其余各项指标均无统计学差异。与此同时，从眶额到双侧中央后叶和颞叶中部皮层的功能连接显著增加。与症状组相比，亚临床组的眶额部灰质体积及其功能连接呈一过性升高。此外，眶额皮质灰质体积与神经病症状评分呈负相关（r =-0.5871，p < 0.001），神经病变残疾评分（r =-0.3682，p = 0.009），以及4个问题中的神经病理性怀疑（r =-0.4403，p = 0.003），与双侧腓神经波幅呈正相关右侧腓肠神经传导速度（r = 0.3181，p = 0.03）。同样，从眶额到中央后皮质的功能连接与冷检测阈值呈正相关（r = 0.3842，p = 0.03），与神经病症状评分呈负相关（r =-0.3460，p = 0.01）。讨论亚临床2型糖尿病多发性神经病的脑功能和形态学改变可作为早期生物标志物。从亚临床阶段研究2型糖尿病多发性神经病的机制是必要的。
Introduction Central and peripheral nervous systems are all involved in type 2 diabetic polyneuropathy mechanisms, but such subclinical changes and associations remain unknown. This study aims to explore subclinical changes of the central and peripheral and unveil their association. Methods A total of 55 type-2 diabetes patients consisting of symptomatic (n = 23), subclinical (n = 12), and no polyneuropathy (n = 20) were enrolled in this study. Cerebral morphology, function, peripheral electrophysiology, and clinical information were collected and assessed using ANOVA and post-hoc analysis. Gaussian random field correction was used for multiple comparison corrections. Pearson/Spearman correlation analysis was used to evaluate the association of the cerebral with the peripheral. Results When comparing the subclinical group with no polyneuropathy groups, no statistical differences were shown in peripheral evaluations except amplitudes of tibial nerves. At the same time, functional connectivity from the orbitofrontal to bilateral postcentral and middle temporal cortex increased significantly. Gray matter volume of orbitofrontal and its functional connectivity show a transient elevation in the subclinical group compared with the symptomatic group. Besides, gray matter volume in the orbitofrontal cortex negatively correlated with the Neuropathy Symptom Score (r = -0.5871, p < 0.001), Neuropathy Disability Score (r = -0.3682, p = 0.009), and Douleur Neuropathique en 4 questions (r = -0.4403, p = 0.003), and also found correlated positively with bilateral peroneal amplitude (r > 0.4, p < 0.05) and conduction velocities of the right sensory sural nerve(r = 0.3181, p = 0.03). Similarly, functional connectivity from the orbitofrontal to the postcentral cortex was positively associated with cold detection threshold (r = 0.3842, p = 0.03) and negatively associated with Neuropathy Symptom Score (r = -0.3460, p = 0.01). Discussion Function and morphology of brain changes in subclinical type 2 diabetic polyneuropathy might serve as an earlier biomarker. Novel insights from subclinical stage to investigate the mechanism of type 2 diabetic polyneuropathy are warranted.
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功能磁共振成像揭示了患有和不患有糖尿病周围神经病变的糖尿病患者对热刺激的大脑激活反应的差异。
影响因子：
3.7
作者：
Li J;Zhang W;Wang X;Yuan T;Liu P;Wang T;Shen L;Huang Y;Li N;You H;Xiao T;Feng F;Ma C
通讯作者：
Ma C
影响因子：
16.2
作者：
Selvarajah, Dinesh;Wilkinson, Iain D.;Tesfaye, Solomon
通讯作者：
Tesfaye, Solomon
影响因子：
9.2
作者：
Singh, Amrita;Patel, Divya;Wang, Jing
通讯作者：
Wang, Jing
影响因子：
7.4
作者：
Chang PC;Centeno MV;Procissi D;Baria A;Apkarian AV
通讯作者：
Apkarian AV
影响因子：
16.2
作者：
Krishnan, Singhan T. M.;Quattrini, Cristian;Jeziorska, Maria;Malik, Rayaz A.;Rayman, Gerry
通讯作者：
Rayman, Gerry