Effect of glycemia on plasma incretins and the incretin effect during oral glucose tolerance test.
Effect of glycemia on plasma incretins and the incretin effect during oral glucose tolerance test.
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DOI：
10.2337/db11-1825
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发表时间：
2012-11
期刊：
影响因子：
7.7
通讯作者：
D'Alessio DA
中科院分区：
文献类型：
--
作者：
Salehi M;Aulinger B;D'Alessio DA
肠促胰岛素效应反映了肠激素胰高血糖素样肽-1（GLP-1）和葡萄糖依赖性促胰岛素多肽等因素对餐后胰岛素分泌的增强作用，其与膳食量成比例增加。然而，肠促胰岛素效应是否依赖于环境葡萄糖尚不清楚。本研究的目的是确定血浆肌酐对肠促胰岛素效应的影响。13名健康受试者在8和10.5 mmol/L的固定高血糖期间分别在3天内摄入50 g与d-木糖混合的口服葡萄糖溶液，两次处于较低血糖值（LOW），一次处于较高血糖值（HIGH）。在固定高血糖下摄入葡萄糖后胰岛素释放的相对增加（肠促胰岛素效应的替代物）在所有三项研究中相似。GLP-1对口服葡萄糖的反应在较高的血浆葡萄糖浓度下显著较低，餐后出现d-木糖也是如此。在两项LOW研究中，单独静脉注射葡萄糖和静脉注射加摄入葡萄糖时胰岛素释放的重现性相似。这些结果表明，肠促胰岛素对餐后胰岛素释放的贡献与健康个体中的胰岛素水平无关，尽管GLP-1分泌存在差异。肠促胰岛素效应在具有正常葡萄糖耐量的人中是可再现的性状。
The incretin effect, reflecting the enhancement of postprandial insulin secretion by factors including the intestinal hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide, increases in proportion to meal size. However, it is unknown whether the incretin effect is dependent on ambient glucose. The goal of this study was to determine the effect of plasma glycemia on the incretin effect. Thirteen healthy subjects consumed 50 g oral glucose solution mixed with d-xylose during fixed hyperglycemia at 8 and 10.5 mmol/L, on 3 separate days, twice at lower glycemia (LOW) and once at higher values (HIGH). The relative increase in insulin release after glucose ingestion at fixed hyperglycemia, a surrogate for the incretin effect, was similar among all three studies. The GLP-1 response to oral glucose was significantly lower at higher plasma glycemia, as was the appearance of d-xylose after the meal. Between the two LOW studies, the reproducibility of insulin release in response to intravenous glucose alone and intravenous plus ingested glucose was similar. These findings indicate that the incretin contribution to postprandial insulin release is independent of glycemia in healthy individuals, despite differences in GLP-1 secretion. The incretin effect is a reproducible trait among humans with normal glucose tolerance.
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影响因子：
5.8
作者：
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通讯作者：
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作者：
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通讯作者：
Holst, JJ
影响因子：
5.8
作者：
Vilsboll, T;Krarup, T;Holst, JJ
通讯作者：
Holst, JJ