Time windows and reverberating loops: a reverse-engineering approach to cerebellar function
Time windows and reverberating loops: a reverse-engineering approach to cerebellar function
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DOI：
10.1080/14734220309426
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发表时间：
2003-01-01
期刊：
影响因子：
3.5
通讯作者：
De Zeeuw, CI
中科院分区：
文献类型：
--
作者：
Kistler, WM;De Zeeuw, CI
我们回顾了小脑功能的逆向工程方法，特别注意神经元相互作用的时间方面。这种方法提供了新的前景GABA能突触的作用和橄榄小脑系统内的反射投射。更具体地说，我们的模拟表明，高尔基体细胞可以控制颗粒细胞的环时间，而不是他们的环率，浦肯野细胞可以触发精确定时的反弹尖峰在小脑深核神经元。这种反弹活动可以反射回小脑皮层，产生复杂的振荡动力学，可能对工作记忆和时间反应任务具有有趣的功能意义。
We review a reverse-engineering approach to cerebellar function that pays particular attention to temporal aspects of neuronal interactions. This approach offers new vistas on the role of GABAergic synapses and reverberating projections within the olivo-cerebellar system. More specifically, our simulations show that Golgi cells can control the ring time of granule cells rather than their ring rate and that Purkinje cells can trigger precisely timed rebound spikes in neurons of the deep cerebellar nuclei. This rebound activity can reverberate back to the cerebellar cortex giving rise to a complex oscillatory dynamics that may have interesting functional implications for working memory and timed-response tasks.