Quantification of left and right ventricular kinetic energy using four-dimensional intracardiac magnetic resonance imaging flow measurements
Quantification of left and right ventricular kinetic energy using four-dimensional intracardiac magnetic resonance imaging flow measurements
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DOI：
10.1152/ajpheart.00942.2011
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发表时间：
2012-02-01
影响因子：
4.8
通讯作者：
Arheden, H.
中科院分区：
文献类型：
--
作者：
Carlsson, M.;Heiberg, E.;Arheden, H.
Carlsson M，Heiberg E，Toger J，Arheden H.使用四维心内磁共振成像血流测量对左、右室动能进行量化。Am J Physiol心圈Physiol 302：H893-H900,2012。2011年12月16日首次出版；doi：10.1152/ajpheart。00942.2011.-我们的目标是使用四维相位对比磁共振成像(MRI)来量化左室(LV)和右室(RV)整个心动周期的动能(KE)。使用内部开发的软件对健康志愿者(n=9)的KE进行了量化。左、右室心动周期的平均KE高度相关(r(2)=0.96)。平均KE与舒张末容量(左心室r(2)=0.66，右室r(2)=0.74)、收缩末容量(r(2)=0.59和0.68)、每搏量(r(2)=0.55和0.60)相关，但与射血分数(r(2)=0.01，P=0.05)无关。收缩、舒张期和舒张期各有3个KE峰。收缩期室壁峰值Ke(4.9±-0.4mJ，P=0.004)低于右室(7.5mJ/-0.8mJ)。反之，左室舒张早期KE(6.0mJ/-0.6mJ，P=0.004)高于右室(3.6mJ/-0.4mJ)。舒张期晚期峰值小于收缩期峰和舒张期早期峰(1.3+/-0.2和1.2+/-0.2mJ)。模型估计了KE占总外部功的比例，这类似于静息时左心室外功的0.3%和RV能量的3%，以及高峰运动时的24%。LV舒张期早期Ke较高，提示LV充盈比RV更依赖于心室吸力。另一方面，右室早期舒张期充盈可能导致房室平面向心底的更高程度的回归。右室流出道长于左室的室壁几何形状的不同，解释了右室较高的收缩压KE。
Carlsson M, Heiberg E, Toger J, Arheden H. Quantification of left and right ventricular kinetic energy using four-dimensional intracardiac magnetic resonance imaging flow measurements. Am J Physiol Heart Circ Physiol 302: H893-H900, 2012. First published December 16, 2011; doi: 10.1152/ajpheart. 00942.2011.-We aimed to quantify kinetic energy (KE) during the entire cardiac cycle of the left ventricle (LV) and right ventricle (RV) using four-dimensional phasecontrast magnetic resonance imaging (MRI). KE was quantified in healthy volunteers (n = 9) using an in-house developed software. Mean KE through the cardiac cycle of the LV and the RV were highly correlated (r(2) = 0.96). Mean KE was related to end-diastolic volume (r(2) = 0.66 for LV and r(2) = 0.74 for RV), end-systolic volume (r(2) = 0.59 and 0.68), and stroke volume (r(2) = 0.55 and 0.60), but not to ejection fraction (r(2) = 0.01, P = not significant for both). Three KE peaks were found in both ventricles, in systole, early diastole, and late diastole. In systole, peak KE in the LV was lower (4.9 +/- 0.4 mJ, P = 0.004) compared with the RV (7.5 +/- 0.8 mJ). In contrast, KE during early diastole was higher in the LV (6.0 +/- 0.6 mJ, P = 0.004) compared with the RV (3.6 +/- 0.4 mJ). The late diastolic peaks were smaller than the systolic and early diastolic peaks (1.3 +/- 0.2 and 1.2 +/- 0.2 mJ). Modeling estimated the proportion of KE to total external work, which comprised similar to 0.3% of LV external work and 3% of RV energy at rest and 3 vs. 24% during peak exercise. The higher early diastolic KE in the LV indicates that LV filling is more dependent on ventricular suction compared with the RV. RV early diastolic filling, on the other hand, may be caused to a higher degree of the return of the atrioventricular plane toward the base of the heart. The difference in ventricular geometry with a longer outflow tract in the RV compared with the LV explains the higher systolic KE in the RV.