Exercise acutely increases circulating endothelial progenitor cells and monocyte-/macrophage-derived angiogenic cells
Exercise acutely increases circulating endothelial progenitor cells and monocyte-/macrophage-derived angiogenic cells
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DOI：
10.1016/j.jacc.2004.02.049
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发表时间：
2004-06-16
影响因子：
24
通讯作者：
March, KL
中科院分区：
文献类型：
--
作者：
Rehman, J;Li, JL;March, KL
背景内皮祖细胞和CACs可以从外周血中分离出来，并且已经被证明参与血管修复和血管生成。我们假设，运动可能会急剧增加循环EPCs或CACs.METHODS志愿者受试者（n = 22）进行了详尽的动态运动。在运动前和运动后抽血，评估循环EPC数量以及血管生成生长因子的血浆水平。结果在外周血中，循环EPCs（AC 133 +/VE-Cadherin+细胞）从66 +/-27 cells/ml增加到236 +/-34 cells/ml，增加了近4倍（p < 0.05）。分离的CAC的数量增加了2.5倍，从外周血的8，754 +/-2，048个细胞/ml增加到20，759 +/-4，676个细胞/ml（p < 0.005）。运动前后分离的血管生成细胞显示出相似的血管生成生长因子的分泌模式。结论我们的研究表明，运动可以急性增加EPCs和CACs。考虑到这些细胞群促进血管生成和血管再生的能力，运动诱导的细胞动员可能充当生理修复或补偿机制。(C)2004年，美国心脏病学会基金会。
OBJECTIVES We investigated whether a single episode of exercise could acutely increase the numbers of endothelial progenitor cells (EPCs) and cultured/circulating angiogenic cells (CACs) in human subjects.BACKGROUND Endothelial progenitor cells and CACs can be isolated from peripheral blood and have been shown to participate in vascular repair and angiogenesis. We hypothesized that exercise may acutely increase either circulating EPCs or CACs.METHODS Volunteer subjects (n = 22) underwent exhaustive dynamic exercise. Blood was drawn before and after exercise, and circulating EPC numbers as well as plasma levels of angiogenic growth factors were assessed. The CACs were obtained by culturing mononuclear cells and the secretion of multiple angiogenic growth factors by CACs was determined.RESULTS Circulating EPCs (AC133+/VE-Cadherin+ cells) increased nearly four-fold in peripheral blood from 66 +/- 27 cells/ml to 236 +/- 34 cells/ml (p < 0.05). The number of isolated CACs increased 2.5-fold from 8,754 +/- 2,048 cells/ml of peripheral blood to 20,759 +/- 4,676 cells/ml (p < 0.005). Cultured angiogenic cells isolated before and after exercise showed similar secretion patterns of angiogenic growth factors.CONCLUSIONS Our study demonstrates that exercise can acutely increase EPCs and CACs. Given the ability of these cell populations to promote angiogenesis and vascular regeneration, the exercise-induced cell mobilization may serve as a physiologic repair or compensation mechanism. (C) 2004 by the American College of Cardiology Foundation.