Muscarinic subtype selectivity of tetrahydroaminoacridine: possible relationship to its capricious efficacy.
Muscarinic subtype selectivity of tetrahydroaminoacridine: possible relationship to its capricious efficacy.
复制标题
四氢氨基吖啶的毒蕈碱亚型选择性：与其反复无常的功效可能有关。
DOI：
10.1016/0014-2999(91)90901-2
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发表时间：
1991
影响因子：
5
通讯作者：
el-Fakahany,EE
中科院分区：
文献类型：
--
作者：
Kiefer-Day,JS;Campbell,HE;Towles,J;el-Fakahany,EE
Tetrahydroaminoacridinc discriminated slightly in its potency to displace [3H]N-methylscopolamine ([3H]NMS) binding from different muscarinic receptor subtypes (M2> M1> M3) and to allosterically decelerate ligand binding (M2⩾ M1> M3). T steep displacement curves suggest that marked changes in receptor occupancy may occur within a relatively narrow dose range. Thus, individual inter-patient variability and inconsistent results in clinical studies may be related to blockade of muscarinic receptors, which would oppose the beneficial effects resulting from acetylcholinesterase inhibition.
