The global burden of ischemic heart disease in 1990 and 2010: the Global Burden of Disease 2010 study.
The global burden of ischemic heart disease in 1990 and 2010: the Global Burden of Disease 2010 study.
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DOI：
10.1161/circulationaha.113.004046
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发表时间：
2014-04-08
期刊：
影响因子：
37.8
通讯作者：
Naghavi M
中科院分区：
文献类型：
--
作者：
Moran AE;Forouzanfar MH;Roth GA;Mensah GA;Ezzati M;Flaxman A;Murray CJ;Naghavi M
缺血性心脏病（IHD）负担包括因IHD死亡而损失的生命年数和因3种非致死性IHD后遗症（非致死性急性心肌梗死、心绞痛和缺血性心力衰竭）而残疾的年数。我们的目的是估计1990年和2010年IHD的全球和区域负担。根据系统综述和非线性混合效应meta回归方法的数据，对1990年和2010年全球和地区急性心肌梗死发病率、心绞痛和心力衰竭患病率按年龄、性别和世界地区进行估计。1990年至2010年，全球年龄标准化急性心肌梗死发病率和心绞痛患病率下降；缺血性心力衰竭患病率略有上升。1990年至2010年期间，IHD的全球负担增加了2900万残疾调整生命年（增加29%）。1990年至2010年间，全球IHD残疾调整生命年增长的32.4%归因于世界人口老龄化，22.1%归因于人口增长，人均IHD负担下降25.3%（下降率）使总残疾调整生命年减少。自1990年以来，患有非致命性IHD的人数增加超过IHD死亡人数，但2010年IHD残疾调整生命年中有90%可归因于IHD死亡。在全球范围内，自1990年以来，年龄标准化急性心肌梗死发病率和心绞痛患病率有所下降，而缺血性心力衰竭患病率有所上升。尽管自1990年以来，大多数地区的年龄标准化致死性和非致死性IHD发病率有所下降，但人口增长和老龄化导致2010年全球IHD负担增加。
Ischemic heart disease (IHD) burden consists of years of life lost from IHD deaths and years of disability lived with 3 nonfatal IHD sequelae: nonfatal acute myocardial infarction, angina pectoris, and ischemic heart failure. Our aim was to estimate the global and regional burden of IHD in 1990 and 2010. Global and regional estimates of acute myocardial infarction incidence and angina and heart failure prevalence by age, sex, and world region in 1990 and 2010 were estimated based on data from a systematic review and nonlinear mixed-effects meta-regression methods. Age-standardized acute myocardial infarction incidence and angina prevalence decreased globally between 1990 and 2010; ischemic heart failure prevalence increased slightly. The global burden of IHD increased by 29 million disability-adjusted life-years (29% increase) between 1990 and 2010. About 32.4% of the growth in global IHD disability-adjusted life-years between 1990 and 2010 was attributable to aging of the world population, 22.1% was attributable to population growth, and total disability-adjusted life-years were attenuated by a 25.3% decrease in per capita IHD burden (decreased rate). The number of people living with nonfatal IHD increased more than the number of IHD deaths since 1990, but >90% of IHD disability-adjusted life-years in 2010 were attributable to IHD deaths. Globally, age-standardized acute myocardial infarction incidence and angina prevalence have decreased, and ischemic heart failure prevalence has increased since 1990. Despite decreased age-standardized fatal and nonfatal IHD in most regions since 1990, population growth and aging led to a higher global burden of IHD in 2010.