DEVELOPMENT OF CIRCADIAN RHYTHMICITY AND LIGHT RESPONSIVENESS IN THE RAT SUPRACHIASMATIC NUCLEUS - A STUDY USING THE 2-DEOXY GLUCOSE-1-C-14 METHOD
DEVELOPMENT OF CIRCADIAN RHYTHMICITY AND LIGHT RESPONSIVENESS IN THE RAT SUPRACHIASMATIC NUCLEUS - A STUDY USING THE 2-DEOXY GLUCOSE-1-C-14 METHOD
复制标题
DOI：
10.1073/pnas.77.2.1204
复制
发表时间：
1980-01-01
期刊：
影响因子：
--
通讯作者：
MOORE, RY
中科院分区：
文献类型：
--
作者：
FUCHS, JL;MOORE, RY
下丘脑视交叉上核（SCN）被认为在昼夜节律的产生和对光/暗周期的诱导中起着关键作用。在成年大鼠中，SCN在代谢活动水平上显示出昼夜节律，如2-脱氧[1- 14 C]葡萄糖摄取所示。研究了这种节律的发展。在出生前1-2天的胎鼠中，摄取无明显的昼夜差异。SCN 2-脱氧葡萄糖摄取的一个显着的昼夜差异存在于出生后第1天，即使在大鼠保持在恒定的黑暗。到第1天，夜间暴露于光下增加了SCN代谢水平。根据之前的研究，第1天，SCN发育不良，突触很少。此时视网膜下丘脑束尚未发育。SCN的功能逐渐成熟，发现通过第21天，当节奏和光反应类似的成年大鼠。
The suprachiasmatic nucleus (SCN) of the hypothalamus is thought to play a critical role in circadian rhythm generation and entrainment to the light/dark cycle. In adult rats, the SCN shows a circadian rhythm in metabolic activity level as indicated by 2-deoxy[1-14C]glucose uptake. The development of this rhythm was investigated. No diurnal difference in uptake was evident in fetal rats 1-2 days before birth. A significant diurnal difference in SCN 2-deoxyglucose uptake was present on postnatal day 1, even in rats kept in constant darkness. By day 1, exposure to light at night increased the SCN metabolic levels. According to previous studies, on day 1 the SCN is poorly developed and contains few synapses. At this time the retinohypothalamic tract has not yet developed. Progressive functional maturation of the SCN was found through day 21, when the rhythm and light responsiveness resembled those of adult rats.