Effect of sex on counterregulatory responses to exercise after antecedent hypoglycemia in type 1 diabetes
Effect of sex on counterregulatory responses to exercise after antecedent hypoglycemia in type 1 diabetes
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DOI：
10.1152/ajpendo.00480.2002
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发表时间：
2004-07-01
影响因子：
5.1
通讯作者：
Davis, SN
中科院分区：
文献类型：
--
作者：
Galassetti, P;Tate, D;Davis, SN
在健康个体中，应激后神经内分泌和代谢反应迟钝的模式存在明显的两性异形。目前尚不清楚1型糖尿病（T1 DM）患者在先前低血糖后进行长时间适度运动时是否会出现显著的性别相关的反调节差异。研究了14例T1 DM患者（7例女性和7例男性）在前一天血糖正常（5.0 mmol/l）或低血糖2.9 mmol/l两次2小时发作后，在50%最大O-2消耗量下进行90分钟的血糖正常运动。男性和女性在年龄、血糖控制、糖尿病持续时间和运动适应性方面相匹配，并且没有自主神经病变的病史或证据。在常规胰岛素（1 U/h）和20%葡萄糖输注的恒定“基础”静脉输注期间进行运动，以维持正常。在所有运动和葡萄糖钳夹研究中，男性和女性的血糖和胰岛素水平相等。先前的低血糖产生相对更大的（P
A marked sexual dimorphism exists in healthy individuals in the pattern of blunted neuroendocrine and metabolic responses following antecedent stress. It is unknown whether significant sex-related counterregulatory differences occur during prolonged moderate exercise after antecedent hypoglycemia in type 1 diabetes mellitus (T1DM). Fourteen patients with T1DM (7 women and 7 men) were studied during 90 min of euglycemic exercise at 50% maximal O-2 consumption after two 2-h episodes of previous-day euglycemia (5.0 mmol/l) or hypoglycemia of 2.9 mmol/l. Men and women were matched for age, glycemic control, duration of diabetes, and exercise fitness and had no history or evidence of autonomic neuropathy. Exercise was performed during constant "basal" intravenous infusion of regular insulin (1 U/h) and a 20% dextrose infusion, as needed to maintain euglycemia. Plasma glucose and insulin levels were equivalent in men and women during all exercise and glucose clamp studies. Antecedent hypoglycemia produced a relatively greater (P