Genetic Diversity and Levels of Expression of Factor H Binding Protein among Carriage Isolates of Neisseria meningitidis
Genetic Diversity and Levels of Expression of Factor H Binding Protein among Carriage Isolates of Neisseria meningitidis
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DOI：
10.1371/journal.pone.0107240
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发表时间：
2014-09-23
期刊：
影响因子：
3.7
通讯作者：
Taha, Muhamed-Kheir
中科院分区：
文献类型：
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作者：
Lemee, Ludovic;Hong, Eva;Taha, Muhamed-Kheir
脑膜炎球菌病的预防可通过靶向H因子结合蛋白（fHbp）的重组疫苗（如4CMenB和rLP 2086）得到改善，该蛋白是脑膜炎奈瑟氏球菌的免疫原性表面组分，作为三种变体之一存在。这种疫苗是否减少了侵袭性分离株的携带，从而诱导群体免疫尚不清楚。我们分析了268个携带菌株的遗传多样性和fHbp的表达水平，并将其与467个侵袭性菌株进行比较。fhbp基因测序结果显示，携带fhbp基因的菌株中，变异2和变异3所占比例较高（p
The prevention of meningococcal disease may be improved by recombinant vaccines such as 4CMenB and rLP2086 that target the factor H binding protein (fHbp), an immunogenic surface component of Neisseria meningitidis present as one of three variants. Whether such vaccines decrease carriage of invasive isolates and thus induce herd immunity is unknown. We analyzed the genetic diversity and levels of expression of fHbp among 268 carriage strains and compare them to those of 467 invasive strains. fhbp gene sequencing showed higher proportions of variants 2 and 3 among carriage isolates (p