Interaction effect of oxytocin receptor (OXTR) rs53576 genotype and maternal postpartum depression on child behavioural problems
Interaction effect of oxytocin receptor (OXTR) rs53576 genotype and maternal postpartum depression on child behavioural problems
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DOI：
10.1038/s41598-019-44175-6
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发表时间：
2019-05-22
影响因子：
4.6
通讯作者：
Takei, Nori
中科院分区：
文献类型：
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作者：
Choi, Damee;Tsuchiya, Kenji J.;Takei, Nori
先前的研究报道了催产素受体基因型（rs53576）和环境因素对青少年心理健康的相互作用。然而，研究结果是混杂的，特别是关于等位基因的类型（即A与G），并且这种相互作用是否出现在发育的早期阶段仍然没有答案。因此，我们在日本使用了一项独特的纵向出生队列样本（n = 568），研究了OXTR rs53576基因型与母亲产后抑郁之间的相互作用是否会对儿童的行为问题产生影响，作为一种环境风险。儿童行为问题（内化问题和外化问题）在儿童6岁时使用优势和困难问卷确定。采用爱丁堡产后抑郁量表在儿童2个月和10个月时测量产妇产后抑郁。结果显示，OXTR rs53576基因型与母亲产后抑郁相互作用对AA基因型儿童外化问题有显著影响（β =0.136, 95% CI 0.032 ~ 0.240），而对GG/GA基因型儿童无显著影响。这表明，易感基因型（即OXTR rs53576等位基因）与环境负担（即母亲产后抑郁）的相互作用可能是婴儿在生命早期易发生行为问题的潜在因素之一。因此，需要特别关注面临环境风险（如产妇产后抑郁症）的儿童，以便提供适当的护理。
Previous studies have reported interaction effects of oxytocin receptor genotype (rs53576) and environmental factors on mental health in youth. However, the findings are mixed, especially regarding the type of allele (i.e., A vs. G), and it remains unanswered whether such an interaction presents at an early stage of development. Thus, using a unique longitudinal birth cohort sample in Japan (n = 568), we examined whether there was an effect of the interaction between the OXTR rs53576 genotype and maternal postpartum depression, as an environmental risk, on behavioural problems in children. Child behavioural problems (internalising and externalising problems) were ascertained using the Strengths and Difficulties Questionnaire when children were 6 years old. Maternal postpartum depression was measured using the Edinburgh Postnatal Depression Scale when children were at 2 months and 10 months of age. The results revealed a significant effect in the interaction between OXTR rs53576 genotype and maternal postpartum depression on externalising problems in children with AA genotype (beta=0.136, 95% CI 0.032 to 0.240), but not in those with GG/GA genotype. This indicates that an interaction of vulnerable genotypes (i.e., A allele of OXTR rs53576) with an environmental burden (i.e. maternal postpartum depression) may be one of the potential elements that predisposes the infant to developing behavioural problems early in life. Hence, special attention needs to be paid to children exposed to environmental risks such as maternal postpartum depression, to facilitate the provision of appropriate care.