BEHAVIORAL AND IMMUNOLOGICAL CONSEQUENCES OF BRIEF MOTHER-INFANT SEPARATION - A SPECIES COMPARISON
BEHAVIORAL AND IMMUNOLOGICAL CONSEQUENCES OF BRIEF MOTHER-INFANT SEPARATION - A SPECIES COMPARISON
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DOI：
10.1002/dev.420230305
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发表时间：
1990-04-01
影响因子：
2.2
通讯作者：
COHEN, JJ
中科院分区：
文献类型：
--
作者：
LAUDENSLAGER, ML;HELD, PE;COHEN, JJ
研究了一次为期两周的母体分离经历对7个月大的帽子猕猴和猪尾猕猴的直接行为和免疫学影响。母体分离与物种依赖的行为变化有关。这两个物种在与分离相关的摄食行为上都有显著的增加。分离和匹配的对照组表现出干扰行为(发声、惊吓、颤抖、发脾气)的增加，这些行为在对照组受试者24-36小时后消退，但在分离的猴子中继续存在，尽管模式依赖于物种。在分离期间，分离的帽子婴儿而不是辫子婴儿的母系护理与这些干扰行为的逐渐减少有关。在一段时间的激动期后，扎辫子的婴儿表现出抑郁阶段，特征是无精打采、退缩的姿势和运动活动减少。作为一个群体，两个物种分离的婴儿在有丝分裂原激活淋巴细胞方面与对照组没有区别，有丝分裂原是免疫活性的一种衡量标准。然而，当考虑到个体的行为反应时，分离过程中淋巴细胞激活的变化与反映紊乱的行为反应显著相关，例如，在体外用有丝分裂原植物血凝素和刀豆蛋白A(T淋巴细胞免疫活性的标志物)刺激后，淋巴细胞激活的变化与发声水平和无精打采的姿势时间有关。商陆有丝分裂原对B淋巴细胞的激活不受分离经历的影响，也与分离后的特定行为反应无关。讨论了评估应激源的情感后果的重要性。
The immediate behavioral and immunological consequences of a single 2-week maternal separation experience were studied in socially housed 7-month old bonnet and pigtail macaques. Maternal separation was associated with species dependent behavioral changes. Both species showed significant increases in ingestive behaviors associated with separation. Separated and matched controls showed an increase in disturbance behaviors (vocalization, startles, shaking, temper-tantrums) that subsided after 24-36 hours in control subjects, but continued, albeit with species-dependent patterns, in the separated monkeys. Allomaternal care of the separated bonnet infants but not the pigtail infants was associated with a progressive reduction of these disturbance behaviors during the separation period. Following a period of agitation, pigtail infants showed a depressive phase characterized by slouched, withdrawn postures and reduced motor activity. As a group, the separated infants of both species were not different from controls with respect to lymphocyte activation by mitogens, a measure of immunocompetence. However, when individual behavioral responses were considered, the change in lymphocyte activation during separation was significantly related to behavioral responses which reflected disturbance, such that the change in lymphocyte activation following in vitro stimulation with the mitogens phytohemagglutinin and Concanavalin A (markers of the immunocompetence of T lymphocytes) was related to levels of vocalization and time spent in slouched postures. The activation of B lymphocytes by pokeweed mitogen was not influenced by the separation experience nor was it associated with specific behavioral responses to separation. The importance of assessing the affective consequences of stressors is discussed.