The Biological Investigation of Prostacyclin in Preeclamptic Women Seen Reduced Endothelial Function
The Biological Investigation of Prostacyclin in Preeclamptic Women Seen Reduced Endothelial Function
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DOI：
10.3109/10641950903322873
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发表时间：
2010-09
影响因子：
1.5
通讯作者：
Tamao Yamamoto;Yoshikatsu Suzuki;K. Kojima;N. Suzumori;Takashi Suzuki
中科院分区：
文献类型：
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作者：
Tamao Yamamoto;Yoshikatsu Suzuki;K. Kojima;N. Suzumori;Takashi Suzuki
客观的。我们的目的是确定前列环素在先兆子痫女性中的生物学研究，通过体内非侵入性技术观察到内皮血管舒张减少。方法。使用高分辨率超声换能器，测定了 15 名非妊娠女性、20 名血压正常孕妇和 20 名先兆子痫女性在反应性充血后的肱动脉直径。测量各组血浆中 6-酮-前列腺素 F1α (6keto-PGF1α) 浓度以及血小板和血清中 3´、5´-环单磷酸腺苷 (环状 AMP) 浓度。结果。反应性充血后 1 分钟血流介导的血管舒张在血压正常的孕妇中高于非孕妇或先兆子痫女性。子痫前期孕妇血浆6酮-PGF1α浓度和血清环磷酸腺苷浓度低于血压正常孕妇。在血小板中存在前列环素类似物的情况下，三组中环磷酸腺苷的增加程度相似。结论。从这些结果来看，血浆中前列环素和血清中环磷酸腺苷的浓度可能较低，可能是由于先兆子痫女性内皮功能降低，前列环素产生减少所致。
Objective. Our aim was to determine the biological investigation of prostacyclin in preeclamptic women seen reduced endothelial vasodilatation by non-invasive technique in vivo. Methods. Using a high resolution ultrasound transducer, diameters of brachial arteries were determined after reactive hyperemia in 15 non-pregnant, 20 normotensive pregnant and 20 preeclamptic women. The concentrations of 6-keto-prostaglandin F1α (6keto-PGF1α) in plasma and the concentrations of adenosine-3´, 5´-cyclic monophosphate (cyclic AMP) in platelets and serum were measured among the groups. Results. Flow-mediated vasodilatation at 1 min after reactive hyperemia was higher in normotensive pregnant than in the non-pregnant or preeclamptic women. The plasma concentration of 6 keto-PGF1α as well as the serum concentration of cyclic AMP were lower in preeclamptic than those in normotensive pregnant women. The increase in cyclic AMP in the presence of a prostacyclin analogue in platelets was seen at similar levels in all three groups. Conclusion. From these results, the concentrations of prostacyclin in plasma and cyclic AMP in serum might be low possibly due to reduced production of prostacyclin in preeclamptic women seen reduced endothelial function.