Chemerin - A new adipokine that modulates adipogenesis via its own receptor
Chemerin - A new adipokine that modulates adipogenesis via its own receptor
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DOI：
10.1016/j.bbrc.2007.08.104
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发表时间：
2007-11-03
影响因子：
3.1
通讯作者：
Sasaki, Shin-ichi
中科院分区：
文献类型：
--
作者：
Roh, Sang-Gun;Song, Sang-Houn;Sasaki, Shin-ichi
Chemerin是一种由脂肪组织分泌的18 kDa蛋白质，据报道通过与chemerin受体（chemerinR）结合来调节免疫系统功能。我们在此证明chemerin也影响脂肪细胞功能。我们的数据表明，chemerin和chemerinR mRNA的表达在脂肪组织中高度表达，其表达水平在高脂饮食喂养的小鼠中上调。在3 T3-L1细胞和人前脂肪细胞向脂肪细胞分化的过程中，chemerin和chemerinR mRNA的表达显著增加。此外，重组chemerin诱导细胞外信号调节激酶1/2（ERK 1/2）的磷酸化和脂解分化的3 T3-L1脂肪细胞。因此，脂肪因子趋化因子可能通过自分泌/旁分泌机制调节脂肪细胞功能。(C)2007爱思唯尔公司All rights reserved.
Chemerin, an 18 kDa protein secreted by adipose tissue, was reported to modulate immune system function through its binding to the chemerin receptor (chemerinR). We herein demonstrate that chemerin also influences adipose cell function. Our data showed that chemerin and chemerinR mRNA expressions were highly expressed in adipose tissues, and that their expression levels were up-regulated in mice fed a high-fat diet. Both chemerin and chemerinR mRNA expression dramatically increased during the differentiation of 3T3-L1 cells and human preadipocytes into adipocytes. Furthermore, recombinant chemerin induced the phosphorylation of extracellular signal-regulated kinases 1/2 (ERK 1/2) and lipolysis in differentiated 3T3-L1 adipocytes. Thus, the adipokine chemerin likely regulates adipocyte function by autocrine/paracrine mechanisms. (C) 2007 Elsevier Inc. All rights reserved.