LASER ABLATION OF HUMAN ATHEROSCLEROTIC PLAQUE WITHOUT ADJACENT TISSUE-INJURY
LASER ABLATION OF HUMAN ATHEROSCLEROTIC PLAQUE WITHOUT ADJACENT TISSUE-INJURY
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DOI：
10.1016/s0735-1097(85)80435-6
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发表时间：
1985-01-01
影响因子：
24
通讯作者：
LAUDENSLAGER, JB
中科院分区：
文献类型：
--
作者：
GRUNDFEST, WS;LITVACK, F;LAUDENSLAGER, JB
用308 nm XeCl准分子激光器对70例人尸体动脉粥样硬化主动脉进行体外照射。改变每脉冲能量、脉冲持续时间和频率。为了比较，60节也照射氩离子和Nd：YAG（钕：钇铝石榴石）激光器在连续模式下操作。将组织固定在福尔马林中，切片并进行显微镜检查。Nd：YAG和氩离子照射的组织表现出一个中央火山口与不规则的边缘和同心区的热和冲击伤。相比之下，受激准分子激光照射的组织具有狭窄的深切口，具有最小的热损伤或没有热损伤。受激准分子激光器显然以不同于连续波Nd：YAG或氩离子激光器的方式汽化组织。锐利的切口边缘和对邻近正常组织的最小损伤表明，准分子激光器比常规使用的医用激光器更适合普通外科和血管内使用。
Samples (70) of human cadaver atherosclerotic aorta were irradiated in vitro using a 308 nm XeCl excimer laser. Energy per pulse, pulse duration and frequency were varied. For comparison, 60 segments were also irradiated with an argon ion and an Nd:YAG (neodymium:yttrium aluminum garnet) laser operated in the continuous mode. Tissue was fixed in formalin, sectioned and examined microscopically. The Nd:YAG and argon ion-irradiated tissue exhibited a central crater with irregular edges and concentric zones of thermal and blast injury. In contrast, the excimer laser-irradiated tissue had narrow deep incisions with minimal or no thermal injury. The excimer laser apparently vaporizes tissue in a manner different from that of the continuous wave Nd:YAG or argon ion laser. The sharp incision margins and minimal damage to adjacent normal tissue suggest that the excimer laser is more desirable for general surgical and intravascular uses than are the conventionally used medical lasers.