XRCC1 polymorphisms, cooking oil fume and lung cancer in Chinese women nonsmokers
XRCC1 polymorphisms, cooking oil fume and lung cancer in Chinese women nonsmokers
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DOI：
10.1016/j.lungcan.2008.03.002
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发表时间：
2008-11-01
期刊：
影响因子：
5.3
通讯作者：
Zhou, Baosen
中科院分区：
文献类型：
--
作者：
Li, Mingchuan;Yin, Zhihua;Zhou, Baosen
X射线修复交叉互补组1（XRCC1）是参与碱基切除修复（BER）和单链断裂修复（SSBR）途径的主要DNA修复蛋白之一。XRCC1中的单核苷酸多态性（SNP）可能改变蛋白质功能和修复能力，从而导致遗传不稳定性和致癌作用。为了了解XRCC1多态性（5'非翻译区.77T>C、Arg194Trp、Arg280His和Arg399Gln）与女性非吸烟者患肺癌易感性之间可能存在的关系，我们进行了一项以医院为基础的病例对照研究，研究对象包括350例新诊断的肺癌患者和350例无癌对照，按年龄进行频数匹配。我们的研究结果表明，接触厨房油烟与中国女性非吸烟者患肺癌的风险增加有关[比值比（OR）=2.51，95%置信区间（CI）[1.80 - 3.51]，P
（最后一个单词“P”后面似乎内容不完整）
X-ray repair cross-complementing group 1 (XRCC1) is one of the major DNA repair proteins involved in the base excision repair (BER) and single-strand break repair (SSBR) pathway. Single nucleotide polymorphisms (SNPs) in XRCC1 may alter protein function and repair capacity, thus lead to genetic instability and carcinogenesis. To establish our understanding of possible relationships between XRCC1 polymorphisms (5'UTR.77T>C, Arg194Trp, Arg280His and Arg399Gln) and the susceptibility to tung cancer among women nonsmokers, we performed a hospital-based case-control study of 350 patients with newly diagnosed lung cancer and 350 cancer-free controls, frequency matched by age. Our results showed that exposure to cooking oil fume was associated with increased risk of lung cancer in Chinese women nonsmokers [odds ratio (OR) = 2.51, 95% confidence interval (CI) [1.80-3.51], P