Effects of long-term synbiotic supplementation in addition to lifestyle changes in children with obesity-related non-alcoholic fatty liver disease
Effects of long-term synbiotic supplementation in addition to lifestyle changes in children with obesity-related non-alcoholic fatty liver disease
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DOI：
10.5152/tjg.2017.17084
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发表时间：
2017-09-01
影响因子：
1.2
通讯作者：
Kaya, Gulay
中科院分区：
文献类型：
--
作者：
Cakir, Murat;Isbilen, Ayse Aksel;Kaya, Gulay
背景/目的：我们的目标是分析一种新的治疗方法，长期联合生物补充剂，以及改变非酒精性脂肪性肝病(NAFLD)儿童的生活方式的有效性。材料和方法：本研究包括28例NAFLD儿童和30例健康对照组。非酒精性脂肪肝患儿每天服用1粒合生素胶囊。分别于治疗前和治疗4个月后进行人体测量、生化分析，包括乙醇、肿瘤坏死因子-α(TNF-α)、总氧化剂状态(TOS)和抗氧化状态(TAS)、透明带蛋白和粪便钙保护素，并进行超声检查。结果：28例患者中有19例(67.8%)脂肪肝分级降低(1级)。治疗结束时，总胆固醇、低密度脂蛋白、肿瘤坏死因子-α、C-反应蛋白、乙醇显著降低，TAS显著升高(P<0.05)。
Background/Aims: We aimed to analyze the efficiency of a novel treatment approach, long-term synbiotic supplementation, in addition to lifestyle changes in children with non-alcoholic fatty liver disease (NAFLD). Materials andMethods: The study included children with NAFLD (n=28) and a healthy control group (n=30). Children with NAFLD were given 1 capsule/day of synbiotics. Anthropometric parameters; biochemical analysis, including ethanol, tumor necrosis factor-alpha (TNF-alpha), total oxidant status (TOS) and anti-oxidant status (TAS), zonulin, and fecal calprotectin; and ultrasonographic examination were performed at baseline and 4 months later.Results: The grade of fatty liver was decreased (>= 1 grade) in 19 of the 28 patients (67.8%) after synbiotic supplementation. Total cholesterol, low-density lipoprotein (LDL) levels, TNF-alpha, C-reactive protein (CRP), and ethanol were significantly decreased, and TAS levels were significantly increased at the end of treatment (p