Isolated liver damage in chemical workers.
Isolated liver damage in chemical workers.
复制标题
化学工人的孤立性肝损伤。
DOI：
10.1136/oem.41.1.142
复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
L. Ranek
中科院分区：
文献类型：
--
作者：
M. Døssing;L. Ranek
在18个月的时间里，3名工人因在化工厂开始工作2至4个月后出现黄疸而入院治疗。肝活检显示严重的小叶中心出血性肝细胞坏死。病变在6~18个月内消失。其他器官未见损伤。唯一在工厂恢复工作的工人出现了肝损伤复发的临床和生化证据。暴露于二硫化碳、异丙醇、甲苯和丙烯腈等，但肝损伤可能是由肝微粒体酶系统介导的协同肝毒性反应引起的。无法确定是哪种化学物质造成的。
During a period of 18 months three workers were admitted to hospital with jaundice that had developed two to four months after beginning work at a chemical plant. Liver biopsies showed severe centrilobular, haemorrhagic liver cell necrosis. The pathological changes resolved within six to 18 months. No damage to other organs was observed. The only worker who resumed work at the plant developed clinical and biochemical evidence of relapse of liver damage. Exposure to carbon disulphide, isopropanol, toluene, and acrylonitrile among others was shown, but liver damage may have been caused by a synergistic, hepatotoxic reaction mediated through the hepatic microsomal enzyme system. It was not possible to decide which chemical was responsible.
丙烯腈：大鼠和小鼠的体内代谢。
DOI：
--
发表时间：
1981
期刊：
Drug metabolism and disposition: the biological fate of chemicals
影响因子：
--
作者：
Ahmed,AE;Patel,K
通讯作者：
Patel,K