Association of Polymorphisms of the Receptor for Advanced Glycation Endproducts Gene with Schizophrenia in a Han Chinese Population.
Association of Polymorphisms of the Receptor for Advanced Glycation Endproducts Gene with Schizophrenia in a Han Chinese Population.
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中国汉族人群晚期糖基化终末产物基因受体多态性与精神分裂症的相关性
DOI：
10.1155/2017/6379639
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发表时间：
2017
影响因子：
--
通讯作者：
Li K
中科院分区：
文献类型：
--
作者：
Fu J;Zuo X;Yin J;Luo X;Li Z;Lin J;Zhao B;Ma G;Li K
晚期糖基化终产物受体（Receptor for Advanced Glycation Endproducts，简称AGEs）是免疫球蛋白超家族的一员，与多种参与炎症损伤和包括精神分裂症在内的多种慢性疾病发展的配体结合。在此，使用SNaPshot技术对923例精神分裂症患者和874例健康对照者进行了SNP（G82 S、-374T/A和-429T/C）基因分型。此外，我们调查了上述SNPs与患者临床精神病性症状和神经认知功能的关系。我们的研究表明，与对照组相比，患者的TC + CC基因型频率和-429T/C多态性中的C等位基因频率显著降低（分别为p = 0.031和p = 0.034）。然而，当使用Bonferroni校正时，显著效应消失（分别为p = 0.093和p = 0.102）。G82 S和-374T/A多态性基因型和等位基因频率在两组间差异无统计学意义。此外，-429 T/C C等位基因携带者的Symbol编码评分略高于TT基因型受试者[p = 0.031和p（corr）= 0.093]。本研究结果提示，SNP-429 T/C多态性可能与精神分裂症的易感性有关。
Receptor for Advanced Glycation Endproducts (RAGE) is a member of the immunoglobulin superfamily that binds diverse ligands involved in the development of inflammatory damage and diverse chronic diseases including schizophrenia. Here, three single-nucleotide polymorphisms (SNPs) (G82S, -374T/A, and -429T/C) in the RAGE gene were genotyped in 923 patients with schizophrenia and 874 healthy-matched controls in a Han Chinese population using the SNaPshot technique. Additionally, we investigated the association among aforementioned SNPs with the clinical psychotic symptoms of the patients and neurocognitive function. Our study demonstrated that the frequencies of the TC + CC genotypes and the C allele in the -429T/C polymorphism were significantly lower in the patients compared with the controls (p = 0.031 and p = 0.034, resp.). However, the significant effect disappeared when using Bonferroni correction (p = 0.093 and p = 0.102, resp.). And there were no significant differences in the genotype and allele frequencies between the patients and the controls for G82S and -374T/A polymorphisms. Additionally, the -429T/C C allele carriers had marginally higher Symbol coding scores than the subjects with the TT genotypes [p = 0.031 and p (corr) = 0.093]. Our data indicate that the RAGE -429T/C polymorphism may be associated with the susceptibility of schizophrenia.