Detection of the Synthetic Coolant Menthone 1,2-Glycerol Ketal in an e-Liquid and in Electronic Waterpipe Aerosols Therefrom.
Detection of the Synthetic Coolant Menthone 1,2-Glycerol Ketal in an e-Liquid and in Electronic Waterpipe Aerosols Therefrom.
复制标题
电子液体及其电子水烟气溶胶中合成冷却剂薄荷酮 1,2-甘油缩酮的检测。
DOI：
10.1021/acs.chemrestox.3c00089
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发表时间：
2023
影响因子：
4.1
通讯作者：
Lucas,EricA
中科院分区：
文献类型：
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作者：
Klupinski,TheodoreP;Strozier,ErichD;Koebel,DavidD;Lucas,EricA
电子尼古丁输送系统（ENDS）中合成冷却剂的存在和毒理学风险尚未得到彻底研究。我们鉴定了浓度为170 μg/mL的薄荷味电子液体中的合成冷却剂薄荷酮1，2-甘油缩酮（MGK）。我们还在气溶胶中检测到MGK，这是用电子水管加热电子液体产生的。MGK最初通过二维气相色谱-飞行时间质谱法在电子液体中检测到。为了避免在气相色谱仪的进样口加热样品可能导致的潜在分析伪影，使用液相色谱-串联质谱法完成电子液体中MGK的定量。在最近的报告中确定了电子液体中的其他合成冷却剂之后，这些结果增加了关于使用ENDS的吸入暴露的知识，并表明未来研究与在ENDS设备中使用含MGK的电子液体相关的潜在吸入毒性的重要性。此外，结果证明了使用液相色谱法定量电子液体中的缩酮的能力。
The presence and toxicological risks of synthetic coolants in electronic nicotine delivery systems (ENDS) have not been thoroughly studied. We identified the synthetic coolant menthone 1,2-glycerol ketal (MGK) in a menthol-flavored e-liquid at a concentration of ∼170 μg/mL. We also detected MGK in aerosols resulting from heating the e-liquid with an electronic waterpipe. MGK was initially detected in the e-liquid by two-dimensional gas chromatography–time-of-flight mass spectrometry. To avoid potential analytical artifacts that could result from heating samples in the injection port of the gas chromatograph, quantitation of MGK in the e-liquid was accomplished using a liquid chromatography–tandem mass spectrometry method. Following recent reports identifying other synthetic coolants in e-liquids, these results add knowledge about inhalation exposures from ENDS use and suggest the importance of future research to study the potential inhalation toxicity related to the use of MGK-containing e-liquids in ENDS devices. Furthermore, the results demonstrate the ability to quantify ketals in e-liquids using liquid chromatography methods.