Clinical and serologic study of four smallpox vaccines comparing variations of dose and route of administration. Standard percutaneous revaccination of children who receive primary subcutaneous vaccination.
Clinical and serologic study of four smallpox vaccines comparing variations of dose and route of administration. Standard percutaneous revaccination of children who receive primary subcutaneous vaccination.
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四种天花疫苗的临床和血清学研究，比较剂量和给药途径的变化。
DOI：
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发表时间：
1977
期刊：
影响因子：
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通讯作者：
M. Mattheis
中科院分区：
文献类型：
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作者：
J. Cherry;J. Connor;K. Mcintosh;A. Benenson;D. Alling;U. T. Rolfe;J. E. Schanberger;M. Mattheis
在皮下接种四种天花疫苗之一六个月后，655名儿童用标准经皮天花疫苗进行了挑战。对再免疫的反应的特征是皮肤反应的显著加速和减少，但没有达到在接受初次免疫的同等组中观察到的程度。如果初次皮下接种后出现“感染”，则再接种后不出现发热。再接种的轻微疫苗相关并发症的总体发生率为2-1/2%。与接受一次或两次成功经皮接种疫苗的儿童相比，再次接种疫苗的中和抗体反应明显降低。皮下接种后经皮接种不推荐作为天花免疫接种的方案，因为不能避免并发症，并且所得中和抗体的发生率和平均滴度较低。
Six months after subcutaneous vaccination with one of four smallpox vaccines, 655 children were challenged with a standard percutaneous smallpox vaccine. Response to reimmunization was characterized by a significant acceleration and diminution of skin response, but not to the degree seen in an equivalent group who had received their primary immunization percutaneously. Fever after revaccination was absent if there had been a "take" with primary subcutaneous vaccination. The overall incidence of minor vaccine-related complications with revaccination was 2-1/2%. The neutralizing antibody response to revaccination was markedly reduced, as compared to that of children who received either one or two successful percutaneous vaccinations. Subcutaneous vaccination followed by percutaneous vaccination is not recommended as a schedule for smallpox immunization, because complications are not avoided, and the incidence and mean titer of resultant neutralizing antibody are low.