Probing the luminal microenvironment of reconstituted epithelial microtissues.
Probing the luminal microenvironment of reconstituted epithelial microtissues.
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DOI：
10.1038/srep33148
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发表时间：
2016-09-13
影响因子：
4.6
通讯作者：
Desai TA
中科院分区：
文献类型：
--
作者：
Cerchiari AE;Samy KE;Todhunter ME;Schlesinger E;Henise J;Rieken C;Gartner ZJ;Desai TA
Polymeric microparticles can serve as carriers or sensors to instruct or characterize tissue biology. However, incorporating microparticles into tissues for in vitro assays remains a challenge. We exploit three-dimensional cell-patterning technologies and directed epithelial self-organization to deliver microparticles to the lumen of reconstituted human intestinal microtissues. We also develop a novel pH-sensitive microsensor that can measure the luminal pH of reconstituted epithelial microtissues. These studies offer a novel approach for investigating luminal microenvironments and drug-delivery across epithelial barriers.
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影响因子：
4.5
作者：
BUCKLER, KJ;VAUGHANJONES, RD
通讯作者：
VAUGHANJONES, RD
影响因子：
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作者：
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DOI：
10.1073/pnas.1117147109
发表时间：
2012-04-17
影响因子：
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DOI：
10.1073/pnas.0707090104
发表时间：
2007-10-23
影响因子：
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