Detection of macrophages in atherosclerotic lesions with cytochrome oxidase.
Detection of macrophages in atherosclerotic lesions with cytochrome oxidase.
复制标题
用细胞色素氧化酶检测动脉粥样硬化病变中的巨噬细胞。
DOI：
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发表时间：
1976
影响因子：
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通讯作者：
O. B. Bayliss
中科院分区：
文献类型：
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作者：
C. Adams;O. B. Bayliss
动脉壁的无氧代谢使得细胞色素氧化酶组织化学方法可以显示其中的巨噬细胞。人脂肪条纹（WHO分级I级）或纤维脂肪（WHO分级II级）中的单核细胞（巨噬细胞）通常局限于内皮下区域。病变合并溃疡、壁血栓形成或内膜出血（WHO分级III）时，病灶组织内新形成的毛细血管周围可见大量单核细胞（巨噬细胞）。与I级和II级动脉粥样硬化病变相比，皮下注射油酸胆固醇诱导的脂质肉芽肿中巨噬细胞数量更多，且分布于整个病变。动脉粥样硬化病变的脂质吸收缓慢或不吸收，部分原因可能是其中巨噬细胞的缺乏。
The anaerobic metabolism of the arterial wall allows macrophages to be demonstrated therein by the cytochrome oxidase histochemical method. Monocytes (macrophages) in human fatty streaks (WHO grade I) or fibrofatty (WHO grade II) human atherosclerotic lesions are normally confined to subendothelial regions. Lesions complicated by ulceration, mural thrombosis or intimal haemorrhage (WHO grade III) showed numerous monocytes (macrophages) around newly-formed capillaries in focal areas of organization. By contrast with grades I and II atherosclerotic lesions, macrophages in lipid granulomas induced by subcutaneous injection of cholesterol oleate are more numerous and distributed throughout the lesion. The slow or absent resorption of lipid from atheromatous lesions may in part result from the paucity of macrophages therein.