Evidence that dopamine within motivation and song control brain regions regulates birdsong context-dependently
Evidence that dopamine within motivation and song control brain regions regulates birdsong context-dependently
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DOI：
10.1016/j.physbeh.2008.06.009
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发表时间：
2008-09-03
影响因子：
2.9
通讯作者：
Riters, Lauren V.
中科院分区：
文献类型：
--
作者：
Heimovics, Sarah A.;Riters, Lauren V.
声音交流对于同种人之间成功的社交互动至关重要，但人们对大脑如何调节适合情境的交流知之甚少。神经递质多巴胺 (DA) 参与调节高度动机、目标导向的行为（包括性动机的歌唱行为），新出现的数据表明，DA 在声音交流中的作用可能会根据其发生的环境而有所不同。为了解决这种可能性，在雄性欧洲椋鸟（Sturnus vulgaris）中探索了免疫标记的酪氨酸羟化酶（TH，儿茶酚胺合成中的限速酶）与繁殖环境内和之外产生的鸣声之间的关系。还进行了多巴胺β-羟化酶（DBH；将 DA 转化为去甲肾上腺素的酶）的免疫细胞化学，以深入了解歌曲和 TH 免疫反应性之间的关系是否反映了多巴胺能或去甲肾上腺素能神经传递。 TH 和 DBH 的测量在鸣叫控制区（HVC、X 区、顶皮层坚固核）和与动机有关的区域（内侧视前核 (POM)、腹侧被盖区 (VTA) 和中脑中央灰质）进行量化。在 X 区，TH 的 POM 和 VTA 测量值与繁殖环境内产生的鸣叫相关，但与繁殖环境之外的鸣叫无关。这些地区的胸径在这两种情况下都与歌曲无关。总之，这些数据表明，歌曲控制和动机大脑区域的 DA 可能与高度目标导向、性动机的发声行为的调节有着更紧密的联系。 (c) 2008 Elsevier Inc. 保留所有权利。
Vocal communication is critical for successful social interactions among conspecifics, but little is known about how the brain regulates context-appropriate communication. The neurotransmitter dopamine (DA) is involved in modulating highly motivated, goal-directed behaviors (including sexually motivated singing behavior), and emerging data suggest that the role of DA in vocal communication may differ depending on the context in which it occurs. To address this possibility, relationships between immunolabeled tyrosine hydroxylase (TH, the rate-limiting enzyme in catecholamine synthesis) and song produced within versus outside of a breeding context were explored in male European starlings (Sturnus vulgaris). Immunocytochemistry for dopamine beta-hydroxylase (DBH; the enzyme that converts DA to norepinephrine) was also performed to provide insight into whether relationships between song and TH immunoreactivity reflected dopaminergic or noradrenergic neurotransmission. Measures of TH and DBH were quantified in song control regions (HVC, Area X, robust nucleus of the acropallium) and regions implicated in motivation (medial preoptic nucleus (POM), ventral tegmental area (VTA), and midbrain central gray). In Area X, POM, and VTA measures of TH correlated with song produced within, but not outside of a breeding context. DBH in these regions did not correlate with song in either context. Together, these data suggest DA in both song control and motivation brain regions may be more tightly linked to the regulation of highly goal-directed, sexually motivated vocal behavior. (c) 2008 Elsevier Inc. All rights reserved.