Adipose-Derived Stem Cells and Platelet-Rich Plasma: Implications for Regenerative Medicine
Adipose-Derived Stem Cells and Platelet-Rich Plasma: Implications for Regenerative Medicine
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DOI：
10.1007/978-94-007-2016-9_34
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发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Kusumoto, Kenji
中科院分区：
文献类型：
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作者：
Kakudo, Natsuko;Kushida, Satoshi;Kusumoto, Kenji
与骨髓来源的干细胞相比，脂肪来源的干细胞（ASC）同样能够分化成多种谱系。由于人体脂肪组织可以很容易地获得大量的局部麻醉下，几乎没有病人的不适，它可以提供一个替代来源的干细胞间充质组织再生和工程。另一方面，富血小板血浆（PRP）含有高浓度的血小板。在血小板的α-颗粒中，存在血小板释放的生长因子，其包括诸如血小板衍生生长因子（PDGF）和转化生长因子（TGF）-β的分子，其刺激细胞增殖和分化，包括用于组织再生的ASC的细胞增殖和分化。ASC和PRP可用于临床病例，而无需担心感染和免疫排斥，因为这些是自体组织和血液。使用这些的组合疗法的功效在伤口愈合、脂肪移植和牙周组织再生领域中已被越来越多地认识到。
Adipose-derived stem cells (ASCs) are equally capable of differentiating into multiple lineages compared with bone marrow-derived stem cells. Because human adipose tissue can be easily obtained in large quantities under local anesthesia with little patient discomfort, it may provide an alternative source of stem cells for mesenchymal tissue regeneration and engineering. On the other hand, platelet-rich plasma (PRP) contains a high concentration of thrombocytes. In a-granules of platelets, there are platelet-released growth factors that include molecules such as platelet-derived growth factor (PDGF) and transforming growth factor (TGF)-beta, which stimulate cell proliferation and differentiation, including those of ASCs for tissue regeneration. ASCs and PRP can be used for clinical cases without concerns for infection and immunological rejection because these are autologous tissue and blood. The efficacy of combination therapy using these has been increasingly recognized in the fields of wound healing, fat grafting, and periodontal tissue regeneration.