Balanced inhibition and excitation drive spike activity in spinal half-centers
Balanced inhibition and excitation drive spike activity in spinal half-centers
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DOI：
10.1126/science.1134960
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发表时间：
2007-01-19
期刊：
影响因子：
56.9
通讯作者：
Hounsgaard, Jorn
中科院分区：
文献类型：
--
作者：
Berg, Rune W.;Alaburda, Aidas;Hounsgaard, Jorn
许多肢体运动都是由交替的屈曲和伸展组成的。然而，潜在的脊柱网络机制仍然不明确。在这里，我们表明，在乌龟有节奏的抓痕网络活动期间，肢体运动神经元的突触兴奋和抑制强度是同相而不是异相变化。在划痕发作的去极化波期间，总神经元电导的抑制和激发峰值。此外，尖峰活动是由去极化突触瞬变而不是起搏器特性驱动的。这些发现表明，平衡的兴奋和抑制以及不规则的放电是某些脊髓网络功能的基本主题。
Many limb movements are composed of alternating flexions and extensions. However, the underlying spinal network mechanisms remain poorly defined. Here, we show that the intensity of synaptic excitation and inhibition in limb motoneurons varies in phase rather than out of phase during rhythmic scratchlike network activity in the turtle. Inhibition and excitation peak with the total neuron conductance during the depolarizing waves of scratch episodes. Furthermore, spike activity is driven by depolarizing synaptic transients rather than pacemaker properties. These findings show that balanced excitation and inhibition and irregular firing are fundamental motifs in certain spinal network functions.