Patterns of gene expression in the neural plate and neural tube subdivide the embryonic forebrain into transverse and longitudinal domains.
Patterns of gene expression in the neural plate and neural tube subdivide the embryonic forebrain into transverse and longitudinal domains.
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DOI：
10.1159/000111190
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发表时间：
1997
影响因子：
2.9
通讯作者：
Kenji Shimamura;Salvador Martínez;Luis Puelles;J. Rubenstein
中科院分区：
文献类型：
--
作者：
Kenji Shimamura;Salvador Martínez;Luis Puelles;J. Rubenstein
胚胎小鼠前脑的神经板和神经管中的基因表达模式的分析表明，在其最早的阶段，神经上皮细胞被细分为分子上不同的域。在这里，在以前的出版物中，我们提供的证据表明，基因表达的模式可以与初级形态发生过程，组织成纵向和横向域的胚胎中枢神经系统的组织原基。纵向域产生的背腹图案的轴向中内胚层和非神经外胚层的信号。横向域（原神经节和神经节）表达不同的基因组合存在于神经板和神经管。
The analysis of gene expression patterns in the neural plate and neural tube of the embryonic mouse forebrain shows that, at its earliest stages, the neuroepithelium is subdivided into molecularly distinct domains. Here, and in previous publications, we provide evidence that the patterns of gene expression can be related to primary morphogenetic processes that organize the histological primordia of the embryonic central nervous system into longitudinal and transverse domains. Longitudinal domains are generated by dorsoventral patterning signals produced by the axial mesendoderm and nonneural ectoderm. Transverse domains (proneuromeres and neuromeres) expressing distinct combinations of genes are present in the neural plate and neural tube.