Mathematical model of collective cell migrations based on cell polarity
Mathematical model of collective cell migrations based on cell polarity
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DOI：
10.1111/dgd.12381
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发表时间：
2017-06-01
影响因子：
2.5
通讯作者：
Haga, Hisashi
中科院分区：
文献类型：
--
作者：
Akiyama, Masakazu;Sushida, Takamichi;Haga, Hisashi
单个细胞向由内部或外部因素产生的细胞极性方向迁移。在没有化学引诱剂等引导的情况下，它们会随机迁移。另一方面，已经观察到细胞群导致系统的集体细胞迁移。例如，盘状犬（Dictyostelium disideum）和Madin-Darby犬肾（上皮）细胞表现出典型的集体细胞迁移模式，如均匀定向迁移和旋转迁移。特别是，实验研究表明，在一些物种中，旋转迁移与器官和组织的形态发生密切相关。因此，我们推测，集体细胞迁移是由细胞的普遍机制控制的。在本文中，我们回顾了与培养皿上集体细胞迁移相关的实际实验数据，并表明基于细胞极性的自推进粒子模型可以准确地代表实际的迁移行为。此外，我们表明，在我们的模型中观察到的集体细胞迁移模式是稳健的。
Individual cells migrate toward the direction of the cell polarity generated by interior or exterior factors. Under situations without guides such as chemoattractants, they migrate randomly. On the other hand, it has been observed that cell groups lead to systematic collective cell migrations. For example, Dictyostelium discoideum and Madin-Darby canine kidney (epithelial) cells exhibit typical collective cell migration patterns such as uniformly directional migration and rotational migration. In particular, it has been suggested from experimental investigations that rotational migrations are intimately related to morphogenesis of organs and tissues in several species. Thus, it is conjectured that collective cell migrations are controlled by universal mechanisms of cells. In this paper, we review actual experimental data related to collective cell migrations on dishes and show that our self-propelled particle model based on the cell polarity can accurately represent actual migration behaviors. Furthermore, we show that collective cell migration modes observed in our model are robust.