Respiration during recovery from exercise: effects of trapping and release of femoral blood flow.
Respiration during recovery from exercise: effects of trapping and release of femoral blood flow.
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DOI：
10.1152/jappl.1989.67.6.2608
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发表时间：
1989-12
影响因子：
3.3
通讯作者：
J. Innes;I. Solarte;A. Huszczuk;E. Yeh;B. Whipp;K. Wasserman
中科院分区：
文献类型：
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作者：
J. Innes;I. Solarte;A. Huszczuk;E. Yeh;B. Whipp;K. Wasserman
为了研究血管和代谢刺激对运动后持续呼吸急促的影响，我们记录了15名正常志愿者在稳态循环运动（80w）后恢复时，阻塞和释放股血流对呼吸的影响。在恢复后的前2分钟内，将大腿上方的手铐充气至200 mmHg，以实现阻塞。与对照组相比，袖带充气显著降低了恢复期的通气（P < 0.001）；随后的压力释放伴随着通气量的增加（平均3.2 l/min），从释放后的第一次呼吸开始。这导致了潮汐末二氧化碳的增加（最大8.3托尔增加），这在释放后的第四次呼吸时首次变得显著，并导致通气量进一步增加。在吸入氧分数为1.0的其他实验中，松开袖带后的第一次呼吸通气增加持续存在，尽管略有减弱（平均2.5 l/min）。当空气中含有5%的二氧化碳作为吸气时，通气反应的模式也相似。袖带释放后通气立即升高，以及对100% O2的持续反应表明，袖带释放引起的血管变化对通气的影响独立于释放的代谢物对已知化学感受器的影响。对5% CO2反应的持续性表明，对CO2敏感的肺传入事件在这些反应中没有主要作用。
To investigate the contribution of vascular and metabolic stimuli to the sustained hyperpnea after exercise, the respiratory effects of obstructing and then releasing the femoral blood flow were recorded in 15 normal volunteers during recovery from steady-state cycle exercise (80 W). Obstruction was achieved using cuffs around the upper thighs, inflated for the first 2 min of recovery to a pressure of 200 mmHg. Cuff inflation significantly reduced ventilation during recovery compared with control (P less than 0.001); the subsequent release of pressure was accompanied by an increase in ventilation (averaging 3.2 l/min), which began on the first breath after release. This preceded a rise in end-tidal CO2 (maximum 8.3 Torr increase), which first became significant on the fourth breath after release and led to a further rise in ventilation. The first-breath increase in ventilation after cuff release persisted, although slightly attenuated (averaging 2.5 l/min), in additional experiments with inspired O2 fraction of 1.0. The pattern of ventilatory response was also similar when the experiments were performed with 5% CO2 in air as the inspirate. The immediate rise in ventilation on cuff release, together with the persistent response on 100% O2, suggests that the vascular changes resulting from cuff release exert an influence on ventilation independent of the effects of released metabolites on the known chemoreceptors. The persistence of the response on 5% CO2 indicates that CO2-sensitive lung afferents do not have a major role in these responses.