Effect of Smoking Abstinence and Reduction in Asthmatic Smokers Switching to Electronic Cigarettes: Evidence for Harm Reversal
Effect of Smoking Abstinence and Reduction in Asthmatic Smokers Switching to Electronic Cigarettes: Evidence for Harm Reversal
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DOI：
10.3390/ijerph110504965
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发表时间：
2014-05-01
影响因子：
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通讯作者：
Russo, Cristina
中科院分区：
文献类型：
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作者：
Polosa, Riccardo;Morjaria, Jaymin;Russo, Cristina
电子烟（e-cigs）作为烟草卷烟的更安全的替代品销售，并已显示出减少其消费。在这里，我们首次报告了电子烟对主观和客观哮喘参数的影响，以及通过改用这些产品戒烟或减少烟草消费的哮喘吸烟者的耐受性。我们回顾性分析了吸烟哮喘患者转换为常规电子烟使用后肺量测定数据、气道高反应性（AHR）、哮喘急性发作和主观哮喘控制的变化。在转换前（基线）和连续两次访视（随访/1，6（+/- 1）个月和随访/2，12（+/- 2）个月）时进行测量。确定了18名吸烟哮喘患者（10名单次使用者，8名双重使用者）。总的来说，肺量测定数据、哮喘控制和AHR有显著改善。这些积极的结果在单一和双重用户中被注意到。报告了急性加重率降低，但不显著。未观察到严重不良事件。这项小型回顾性研究表明，定期使用电子烟替代吸烟与哮喘结果的客观和主观改善有关。考虑到据报道电子烟的使用比传统吸烟危害更小，并且可以减少卷烟消费量，随后改善哮喘结果，这项研究表明，电子烟可以成为无法通过其他方法戒烟的哮喘患者的有效选择。
Electronic cigarettes (e-cigs) are marketed as safer alternatives to tobacco cigarettes and have shown to reduce their consumption. Here we report for the first time the effects of e-cigs on subjective and objective asthma parameters as well as tolerability in asthmatic smokers who quit or reduced their tobacco consumption by switching to these products. We retrospectively reviewed changes in spirometry data, airway hyper-responsiveness (AHR), asthma exacerbations and subjective asthma control in smoking asthmatics who switched to regular e-cig use. Measurements were taken prior to switching (baseline) and at two consecutive visits (Follow-up/1 at 6 (+/- 1) and Follow-up/2 at 12 (+/- 2) months). Eighteen smoking asthmatics (10 single users, eight dual users) were identified. Overall there were significant improvements in spirometry data, asthma control and AHR. These positive outcomes were noted in single and dual users. Reduction in exacerbation rates was reported, but was not significant. No severe adverse events were noted. This small retrospective study indicates that regular use of e-cigs to substitute smoking is associated with objective and subjective improvements in asthma outcomes. Considering that e-cig use is reportedly less harmful than conventional smoking and can lead to reduced cigarette consumption with subsequent improvements in asthma outcomes, this study shows that e-cigs can be a valid option for asthmatic patients who cannot quit smoking by other methods.