CIS-DIAMMINEDICHLOROPLATINUM (NSC-119875) IN CHILDHOOD MALIGNANCIES - SOUTHWEST ONCOLOGY GROUP STUDY
CIS-DIAMMINEDICHLOROPLATINUM (NSC-119875) IN CHILDHOOD MALIGNANCIES - SOUTHWEST ONCOLOGY GROUP STUDY
复制标题
DOI：
10.1002/mpo.2950040208
复制
发表时间：
1978-01-01
期刊：
影响因子：
--
通讯作者：
BRYAN, H
中科院分区：
文献类型：
--
作者：
NITSCHKE, R;STARLING, KA;BRYAN, H
对常规治疗耐药的恶性肿瘤患儿给予顺铂（PDD），15-20 mg/m2，每日快速静脉输注，连续5天，间隔3周。24例急性淋巴细胞白血病（ALL）患儿中有11例接受了2个或2个以上疗程。其中未发生缓解。治疗了54例儿童实体瘤：神经母细胞瘤25例，横纹肌肉瘤9例，尤文肉瘤4例，睾丸胚胎癌2例，视网膜母细胞瘤2例，其他肿瘤12例。1例完全缓解，3例部分缓解，2例好转。一个女孩与转移性骨肉瘤取得了部分缓解。一个转移性睾丸胚胎癌的孩子表现出改善。副作用是26名儿童的呕吐被止吐药控制，14名儿童的血清肌酐和BUN [血面积氮]一过性升高。39例接受1个疗程以上PDD治疗的实体瘤患儿中有19例发生了中重度PDD引起的骨髓抑制。PDD在神经母细胞瘤、成骨肉瘤和睾丸胚胎癌中是一种有前途的药物，而在ALL中是无效的药物。PDD对其他类型实体瘤的影响应在未来进行评估。
Children with malignancies resistant to conventional therapy were treated with cis-diamminedichloroplatinum (PDD), 15-20 mg/m2, given daily by rapid i.v. infusion for 5 days at 3-wk intervals. Eleven of 24 children with acute lymphocytic leukemia (ALL) received 2 or more courses. Among these no remissions occurred. Fifty-four children with solid tumors were treated: 25 neuroblastoma, 9 rhabdomyosarcoma, 4 Ewing sarcoma, 2 testicular embryonal carcinoma, 2 retinoblastoma and 12 miscellaneous tumors. One complete remission, 3 partial remissions and 2 improvements were observed in children with neuroblastoma. One girl with metastatic osteogenic sarcoma achieved a partial remission. One child with metastatic testicular embryonal carcinoma showed improvement. The side effects were vomiting controlled by antiemetics in 26 children and transient elevations of serum creatinine and BUN [blood area nitrogen] in 14 children. Nineteen of 39 children with solid tumors, who received more than 1 course of PDD, had moderately severe myelosuppression caused by PDD. PDD is a promising agent in neuroblastoma, osteogenic sarcoma and testicular embryonal carcinoma, and an ineffective agent in ALL. The effect of PDD on other types of solid tumors should be evaluated in the future.