Irijimasides A-E, Macrolide Glycosides from an Okeania sp. Marine Cyanobacterium
Irijimasides A-E, Macrolide Glycosides from an Okeania sp. Marine Cyanobacterium
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Irijimasides A-E，来自 Okeania sp 的大环内酯糖苷。
DOI：
10.1021/acs.jnatprod.0c00042
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发表时间：
2020
影响因子：
5.1
通讯作者：
Toshiaki Teruya
中科院分区：
文献类型：
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作者：
Aki Yamano;Noriyuki Natsume;Miki Yamada;Shimpei Sumimoto;Arihiro Iwasaki;Kiyotake Suenaga;Toshiaki Teruya
Irijimaside A-E(1-5)是一系列新的14元大环内酯苷类化合物，从冲绳的海洋蓝藻中分离得到。1-5的大体结构是通过光谱分析确定的，包括2D核磁共振，绝对立体结构是基于NOESY谱、化学衍生化和电子捕获数据确定的。5个大环内酯类化合物均抑制核因子受体激活剂κB配体(RANKL)诱导的RAW264巨噬细胞抗酒石酸酸性磷酸酶(TRAP)活性，表明这些化合物抑制破骨细胞的形成。
Irijimasides A–E (1–5), a series of new 14-membered macrolide glycosides, were isolated from a marine cyanobacterium collected in Okinawa. The gross structures of1–5were established by spectroscopic analysis, including 2D NMR, while absolute stereostructures were determined based on NOESY spectra, chemical derivatization, and ECD data. All five macrolides suppressed receptor activator of nuclear factor-κB ligand (RANKL)-induced tartrate-resistant acid phosphatase (TRAP) activity in mouse RAW264 macrophage cells, indicating that these compounds inhibit osteoclast formation.