Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95
Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95
复制标题
DOI：
10.1126/science.274.5289.990
复制
发表时间：
1996-11-08
期刊：
影响因子：
56.9
通讯作者：
Dixit, VM
中科院分区：
文献类型：
--
作者：
Chinnaiyan, AM;ORourke, K;Dixit, VM
肿瘤坏死因子受体-1(TNFR-1)和CD95(也称为Fas或APO-I)是细胞因子受体，它们通过细胞内同源区域参与细胞凋亡途径，被称为“死亡结构域”。死亡受体3(Death Receptor 3，DR3)是TNFR家族中另一个含有死亡结构域的成员，它可以诱导细胞凋亡和核因子kappaB的激活。DR3的表达似乎仅限于富含淋巴细胞的组织。DR3信号转导是由Tradd、TRAF2、FADD和FLICE等细胞内信号分子组成的复合体介导的。因此，DR3可能在调节淋巴细胞动态平衡方面发挥作用。
Tumor necrosis factor receptor-1 (TNFR-1) and CD95 (also called Fas or APO-I) are cytokine receptors that engage the apoptosis pathway through a region of intracellular homology, designated the ''death domain.'' Another death domain-containing member of the TNFR family, death receptor 3 (DR3), was identified and was shown to induce both apoptosis and activation of nuclear factor kappa B. Expression of DR3 appears to be restricted to tissues enriched in lymphocytes. DR3 signal transduction is mediated by a complex of intracellular signaling molecules including TRADD, TRAF2, FADD, and FLICE. Thus, DR3 likely plays a role in regulating lymphocyte homeostasis.