Association Between Brain Activation and Functional Connectivity
Association Between Brain Activation and Functional Connectivity
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DOI：
10.1093/cercor/bhy077
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发表时间：
2019-05-01
期刊：
影响因子：
3.7
通讯作者：
Volkow, Nora D.
中科院分区：
文献类型：
--
作者：
Tomasi, Dardo;Volkow, Nora D.
功能性磁共振成像（fMRI）记录的“静息状态”大脑活动的起源仍然不确定。在这里，我们提供的低频波动（ALFF）和局部功能连接密度（IFCD）的振幅的神经血管起源的证据，通过比较它们与任务诱导的血氧水平依赖（BOLD）的反应，这被认为是神经元激活的代理。使用人类连接组项目在426名健康成年人中收集的2种不同任务（关系和社会）的fMRI数据，我们表明ALFF和lFCD与BOLD反应具有线性相关性。这种关联显着减弱了一种新的任务信号回归（TSR）程序，表明任务性能增强IFCD和ALFF在激活区域。我们还表明，lFCD预测BOLD激活模式，如最近所示的其他功能连接指标，这证实了休息功能连接架构影响大脑激活反应。因此，我们的研究结果表明，BOLD反应，ALFF和IFCD，这是一致的局部血流动力学同步性的神经血管起源，大概反映了协调的神经元活动的波动的共同来源。这项研究也支持任务诱发的功能连接密度映射的发展。
The origin of the "resting-state" brain activity recorded with functional magnetic resonance imaging (fMRI) is still uncertain. Here we provide evidence for the neurovascular origins of the amplitude of the low-frequency fluctuations (ALFF) and the local functional connectivity density (lFCD) by comparing them with task-induced blood-oxygen level dependent (BOLD) responses, which are considered a proxy for neuronal activation. Using fMRI data for 2 different tasks (Relational and Social) collected by the Human Connectome Project in 426 healthy adults, we show that ALFF and lFCD have linear associations with the BOLD response. This association was significantly attenuated by a novel task signal regression (TSR) procedure, indicating that task performance enhances lFCD and ALFF in activated regions. We also show that lFCD predicts BOLD activation patterns, as was recently shown for other functional connectivity metrics, which corroborates that resting functional connectivity architecture impacts brain activation responses. Thus, our findings indicate a common source for BOLD responses, ALFF and lFCD, which is consistent with the neurovascular origin of local hemodynamic synchrony presumably reflecting coordinated fluctuations in neuronal activity. This study also supports the development of task-evoked functional connectivity density mapping.