THE PROGNOSTIC-SIGNIFICANCE OF POSTNATAL-GROWTH IN VERY LOW-BIRTH-WEIGHT INFANTS
THE PROGNOSTIC-SIGNIFICANCE OF POSTNATAL-GROWTH IN VERY LOW-BIRTH-WEIGHT INFANTS
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DOI：
10.1016/0002-9378(82)90117-x
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发表时间：
1982-01-01
影响因子：
9.8
通讯作者：
FANAROFF, AA
中科院分区：
文献类型：
--
作者：
HACK, M;MERKATZ, IR;FANAROFF, AA
为了研究足月前后宫内生长衰竭、宫外生长衰竭的相对重要性，以及追赶生长的预后意义，我们对192名极低出生体重儿（< 1.5 kg）进行了前瞻性随访，直至8个月矫正年龄。适当胎龄（AGA）[154]和38名小胎龄（SGA）婴儿在足月（40周）和8月龄时被分为正常体重和亚正常体重（< -2 SD）。到足月，71例AGA婴儿体重低于正常水平；其中41例达到8个月，另有13例AGA婴儿在足月至8个月期间未能茁壮成长。SGA婴儿中，3例达到足月体重，另有16例达到8个月体重。体重不正常的显著相关因素包括新生儿风险评分、慢性病发病率和延长住院时间。与正常胎儿和出生后发育的AGA和SGA婴儿相比，未发育或未赶上体重8 mmol的AGA和SGA婴儿的平均Bayley发育商较低（P < 0.005），头围较小（P < 0.005），神经感觉障碍发生率较高（P < 0.01）。足月前的宫内和/或产后生长衰竭如果发生在足月后，则没有不良的预后意义。
To examine the relative importance of intrauterine growth failure, extrauterine growth failure before or after term, and the prognostic significance of catch-up growth, 192 very low birth weight [human] infants (< 1.5 kg) were followed prospectively to 8 mo. corrected age. Appropriate-for-gestational age (AGA) [154] and 38 small-for-gestational age (SGA) infants were categorized into normal and subnormal (< -2 SD) weight for age groups at term (40 wk) and at 8 mo. corrected age. By term, 71 AGA infants had subnormal weight; 41 of these caught up by 8 mo. and an additional 13 AGA infants failed to thrive between term and 8 mo. Of the SGA infants, 3 caught up in weight by term and an additional 16 caught up by 8 mo. Significant correlates of subnormal weight included neonatal risk score, incidence of chronic disease and extended hospitalization. AGA and SGA infants who failed to thrive or failed to catch up in weight by 8 mo. had lower mean Bayley developmental quotients (P < 0.005), smaller head circumferences (P < 0.005) and a higher rate of neurosensory impairment (P < 0.01) than the AGA infants with normal fetal and postnatal growth. Intrauterine and/or postnatal growth failure prior to term was not of sinister prognostic significance if catch-up occurred thereafter.