Chromosomal aberrations in lymphocytes of healthy subjects and risk of cancer
Chromosomal aberrations in lymphocytes of healthy subjects and risk of cancer
复制标题
DOI：
10.1289/ehp.6925
复制
发表时间：
2005-05-01
影响因子：
10.4
通讯作者：
Srám, RJ
中科院分区：
文献类型：
--
作者：
Rossner, P;Boffetta, P;Srám, RJ
有证据表明，外周血淋巴细胞染色体畸变率的增加是癌症的预测因子，但还需要更多的数据来更好地将染色体畸变率作为癌症风险的标志。我们从15个实验室的档案中收集了11,834名受试者的细胞遗传学记录，这些受试者在抽血时没有患癌症，并在1975-2000年期间为预防目的在捷克共和国接受了细胞遗传学检查。我们将这些记录与国家癌症登记处联系起来，共披露了485例癌症病例。受试者根据CA在每个实验室内的分布百分位数被分为低(0-33个百分位数)、中(34-66个百分位数)和高(66-100个百分位数)。受试者进一步按职业暴露和CA的亚类进行分类。我们发现总体癌症发病率与染色体类型异常的存在显著相关[高CA水平与低CA水平的相对风险(RR)=1.24；95%可信区间(CI)为1.03-1.50]，但与染色单体类型异常无关。胃癌与总CA频率密切相关(RR=7.79；95%CI，1.01-60-0)。暴露于各种致癌物的受试者与未接触致癌物的受试者相比，CA的预测性并无显著差异。这项研究有助于确认CA作为癌症风险的预测标记物，特别是胃癌；CA频率和癌症风险之间的关联可能仅限于染色体类型的异常。
There is evidence that increased frequency of chromosomal aberration (CA) in peripheral blood lymphocytes is a predictor of cancer, but further data are needed to better characterize CA as marker of cancer risk. From the archives of 15 laboratories we gathered cytogenetic records of 11,834 subjects who were free of cancer at the moment of blood drawing and who underwent cytogenetic examination for preventive purposes in the Czech Republic during 1975-2000. We linked these records to the national cancer registry, revealing a total of 485 cancer cases. Subjects were classified according to the percentiles of CA distribution within each laboratory as low (0-33rd percentile), medium (34-66th percentile), and high (66-100th percentile). Subjects were further classified by occupational exposure and by subclass of CA. We found a significant association between the overall cancer incidence and the presence of chromosome-type aberrations [relative risk (RR) for high vs. low CA level = 1.24; 95% confidence interval (Cl), 1.03-1.50] but not chromatid-type aberrations. Stomach cancer showed a strong association with frequency of total CA (RR = 7.79; 95% Cl, 1.01-60-0). The predictivity of CA observed in subjects exposed to various classes of carcinogens did not significantly differ from the group of nonexposed subjects. This study contributes to validation of CA as a predictive marker of cancer risk, in particular, of stomach cancer; the association between CA frequency and cancer risk might be limited to chromosome-type aberrations.