Antigenic variation by Borrelia hermsii occurs through recombination between extragenic repetitive elements on linear plasmids
Antigenic variation by Borrelia hermsii occurs through recombination between extragenic repetitive elements on linear plasmids
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DOI：
10.1111/j.1365-2958.2006.05177.x
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发表时间：
2006-06-01
影响因子：
3.6
通讯作者：
Barbour, Alan G.
中科院分区：
文献类型：
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作者：
Dai, Qiyuan;Restrepo, Blanca I.;Barbour, Alan G.
通过一个存档的可变抗原基因对线性质粒上一个独特表达位点的基因转化，回归热病原体赫氏疏螺旋体经历了多相抗原变异。为了进一步表征这一机制，我们通过对85%携带这些基因的质粒进行测序，评估了存档的可变抗原基因的库和组织。大多数存档基因与表达基因a共享
The relapsing fever agent Borrelia hermsii undergoes multiphasic antigenic variation through gene conversion of a unique expression site on a linear plasmid by an archived variable antigen gene. To further characterize this mechanism we assessed the repertoire and organization of archived variable antigen genes by sequencing similar to 85% of plasmids bearing these genes. Most archived genes shared with the expressed gene a