Regulatory roles of mitochondria and metabolism in neurogenesis.
Regulatory roles of mitochondria and metabolism in neurogenesis.
复制标题
线粒体和代谢在神经发生中的调节作用。
DOI：
10.1016/j.conb.2021.05.003
复制
发表时间：
2021-08
影响因子：
5.7
通讯作者：
Vanderhaeghen P
中科院分区：
文献类型：
--
作者：
Iwata R;Vanderhaeghen P
神经干细胞（Neural Stem Cells，NSCs）在向神经元分化的过程中发生了大量的分子和细胞变化。这些包括线粒体和代谢重塑，这被认为是大多数许可的线索，但最近的工作表明，它们与神经发生有因果关系。神经干细胞在有丝分裂后线粒体发生明显的重构，影响有丝分裂后子细胞的自我更新或分化。向神经元命运的转变需要代谢重新布线，包括增加的氧化磷酸化活性，其驱动转录和表观遗传效应以影响细胞命运。线粒体代谢途径也以重要的方式调节NSC增殖和自我更新。线粒体和代谢对神经发生的影响从苍蝇到人类系统都是保守的，但也显示出与细胞环境或物种有关的显着差异。这些新发现对我们理解神经发育疾病和可能的人类大脑进化具有重要意义。有丝分裂后的线粒体动力学控制神经元的命运承诺。发育代谢变化驱动神经干细胞扩增和分化。代谢中间体通过翻译后修饰影响神经发生。三羧酸循环相关基因的缺失损害胚胎和成人脑中的神经发生。线粒体动力学和功能的物种差异可能与神经发生的进化有关。
Neural stem cells (NSCs) undergo massive molecular and cellular changes during neuronal differentiation. These include mitochondria and metabolism remodelling, which were thought to be mostly permissive cues, but recent work indicates that they are causally linked to neurogenesis. Striking remodelling of mitochondria occurs right after mitosis of NSCs, which influences the postmitotic daughter cells towards self-renewal or differentiation. The transitioning to neuronal fate requires metabolic rewiring including increased oxidative phosphorylation activity, which drives transcriptional and epigenetic effects to influence cell fate. Mitochondria metabolic pathways also contribute in an essential way to the regulation of NSC proliferation and self-renewal. The influence of mitochondria and metabolism on neurogenesis is conserved from fly to human systems, but also displays striking differences linked to cell context or species. These new findings have important implications for our understanding of neurodevelopmental diseases and possibly human brain evolution. Mitochondrial dynamics after mitosis controls neuronal fate commitment. Developmental metabolic shifts drive neural stem cell amplification and differentiation. Metabolic intermediates impact neurogenesis through post-translational modifications. Loss of tricarboxylic acid cycle–associated genes impairs neurogenesis in the embryonic and adult brain. Species differences in mitochondria dynamics and function could be linked to the evolution of neurogenesis.
登录
查看更多内容
影响因子：
16.2
作者：
Beckervordersandforth R;Ebert B;Schäffner I;Moss J;Fiebig C;Shin J;Moore DL;Ghosh L;Trinchero MF;Stockburger C;Friedland K;Steib K;von Wittgenstein J;Keiner S;Redecker C;Hölter SM;Xiang W;Wurst W;Jagasia R;Schinder AF;Ming GL;Toni N;Jessberger S;Song H;Lie DC
通讯作者：
Lie DC
影响因子：
64.5
作者：
Chang CH;Curtis JD;Maggi LB Jr;Faubert B;Villarino AV;O'Sullivan D;Huang SC;van der Windt GJ;Blagih J;Qiu J;Weber JD;Pearce EJ;Jones RG;Pearce EL
通讯作者：
Pearce EL
神经元分化过程中的代谢重编程
影响因子：
12.4
作者：
通讯作者：
--
影响因子：
16.2
作者：
Bonnefont, Jerome;Tiberi, Luca;Vanderhaeghen, Pierre
通讯作者：
Vanderhaeghen, Pierre
影响因子：
64.5
作者：
Homem, Catarina C. F.;Steinmann, Victoria;Knoblich, Juergen A.
通讯作者：
Knoblich, Juergen A.